Indrajit Karmakar

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Curcuma caesia Roxb. (Zingiberaceae), called black turmeric in English, is a perennial herb found throughout the Himalayan region, North-East and Central India. The plant has been traditionally used in India for several medicinal purposes. The present study was carried out to evaluate the methanol extract of C. caesia rhizome (MECC) for some(More)
ETHNOPHARMACOLOGICAL RELEVANCE Anthocephalus cadamba (Roxb.) Miq. (Family: Rubiaceae) is commonly known as "Kadamba" in Sanskrit and Hindi in India. Various parts of this plant have been used as a folk medicine for the treatment of tumor, wound healing, inflammation and as a hypoglycemic agent. AIM OF STUDY The purpose of this investigation was to(More)
Deflazacort (DFZ) is a synthetic oxazoline derivative of prednisolone which comes under the classification of glucocorticoid. In the present study, toxicity of deflazacort on embryo development stage was evaluated using zebrafish embryos, in order to decrease the side effect and causalities. Zebrafish offer practical advantages as powerful in vivo model(More)
Free radical is defined as unstable, highly reactive atom or molecule possessing unpaired electrons, which induces free radical damage. Reactive oxygen species (ROS) are widely believed to be involved in the etiology of many diseases such as ageing, cancer, coronary heart disease, Alzheimer’s disease, neurodegenerative disorders, atherosclerosis, cataracts(More)
Methanol extracts of Thevetia peruviana (METP) (Apocynaceae) fruit showed antitumor activity against Ehrlich's ascites carcinoma (EAC) cell line in Swiss albino mice. The METP-treated group's tumor volume, tumor weight, and viable cell count were decreased compared to the EAC control group. Tumor volumes were 3.62±0.12 ml, 2.88±0.23 ml, and 1.34±0.17 ml for(More)
CONTEXT Many of the major chemotherapeutic agents are secondary metabolites found in nature. Zanthoxylum alatum Roxb. (Rutaceae) is traditionally used in the treatment of various diseases. OBJECTIVE The present study evaluates the apoptotic activity of methanol extract of Z. alatum (MEZA) on Ehrlich ascites tumor (EAT) in Swiss albino mice. MATERIALS(More)
Curcuma caesia Roxb. (Zingiberaceae), known as black turmeric in English, is a perennial herb found throughout the Himalayan region, North-East and Central India. The plant has been traditionally used in India for several medicinal purposes. Present study was carried out to evaluate the methanol extract of C. caesia (MECC) rhizome for some in vitro(More)
Castanopsis indica (Roxb. ex Lindl.) A.DC. (Fagaceae) is commonly known as ‘Dhalne katus’ and ‘Indian chestnut tree’, found throughout the Himalayan region. The purpose of this investigation was to evaluate the effect of methanol extract of C. indica leaves (MECI) on Central Nervous System using a number of neuropharmacological experimental models in Swiss(More)
Methanol extract of C. indica (MECI) leaves showed direct cytotoxicity on Ehrlich ascites carcinoma (EAC) cell in a dose dependant manner and there was significant decrease in the tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Hematological profile and biochemical estimations were significantly restored(More)
The present study assessed the methanol extract of Streblus asper stem bark (MESA) for antitumor effect and antioxidant influence against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Twenty four hours after intraperitonial inoculation of tumor (EAC) cells in mice, MESA was administered at 200 and 400 mg/kg body weight daily for 9 consecutive days.(More)