Indira Munagala

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Patients with HIV-associated tuberculosis (TB) initiating antiretroviral therapy (ART) may develop immune reconstitution inflammatory syndrome (TB-IRIS). No biomarkers for TB-IRIS have been identified and the underlying mechanisms are unclear. Here we perform transcriptomic profiling of the blood samples of patients with HIV-associated TB. We identify(More)
About half of all subjects with common variable immune deficiency (CVID) are afflicted with inflammatory complications including hematologic autoimmunity, granulomatous infiltrations, interstitial lung disease, lymphoid hyperplasia and/or gastrointestinal inflammatory disease. The pathogenesis of these conditions is poorly understood but singly and in(More)
Understanding the developmental mechanisms of T follicular helper (T FH) cells in humans is a highly relevant topic to clinic. However, factors that drive human CD4 + helper T (T H) cell differentiation program towards T FH cells remain largely undefined. Here we show that TGF-β provides critical additional signals for the transcription factors STAT3 and(More)
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