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Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascular tone. We therefore set out to test(More)
The current paper is a Perspective & New Opinion article that offers the term “Vascular pseudo-ossification” as a new term for “vascular calcification” phenomenon in chronic kidney disease (CKD). Vascular calcification is a well-documented complication of CKD. Patients with CKD develop extensive medial calcification, which causes increased arterial(More)
INTRODUCTION The antioxidant protein haptoglobin (Hp) plays a major role in the development of diabetic complications such as diabetic nephropathy and retinopathy. In humans, two alleles of Hp were identified: 1 and 2 with three possible genotypes: 1-1, 2-1, and 2-2. The Hp protein products differ in their biochemical and biophysical properties, such as(More)
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