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Infection with herpes simplex virus type 1 (HSV-1) causes the most common skin disease. Various test systems have been established to recapitulate this cyclical pathway of productive infection, latency, and reactivation. Most studies of latency and reactivation are conducted in animal models. However, the small number of neurons which harbor the viral(More)
Advances in the understanding of the infection and reactivation process of herpes simplex type 1 (HSV-1) are generally gained by monolayer cultures or extensive and cost-intensive animal models. So far, no reliable in vitro skin model exists either to investigate the molecular mechanisms involved in controlling latency and virus reactivation or to test(More)
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