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RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells
TLDR
It is shown that RhoGDI2 functions in the epithelial-mesenchymal transition (EMT), which is responsible for invasiveness during tumor progression, and plays a critical role in tumor progression in gastric cancer through induction of EMT.
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14-3-3σ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells
TLDR
14-3-3σ is a RhoGDI2-regulated gene that appears to be important for suppressing the chemoresistance of gastric cancer cells.
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RhoGDI2 Expression Is Associated with Tumor Growth and Malignant Progression of Gastric Cancer
TLDR
The findings indicate that RhoGDI2 is involved in gastric tumor growth and metastasis, and that RHoGDI 2 may be a useful marker for tumor progression of human gastric cancer.
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RhoGDI2 confers gastric cancer cells resistance against cisplatin-induced apoptosis by upregulation of Bcl-2 expression.
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VEGF‐C mediates RhoGDI2‐induced gastric cancer cell metastasis and cisplatin resistance
TLDR
The results indicate that RhoGDI2 might be a potential therapeutic target for simultaneously reducing metastasis risk and enhancing chemotherapy efficacy in gastric cancer.
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The fatty acid chain elongase, Elovl1, is required for kidney and swim bladder development during zebrafish embryogenesis
TLDR
It is found that both elovl1 knockdown embryos contain increased levels of long chain fatty acids from carbon number 14 to 20 as compared to control embryos, and oil-Red-O staining shows that yolk lipid consumption is greatly reduced, whereas lipid droplets accumulate within the swim bladder.
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PLCγ is required for RhoGDI2-mediated cisplatin resistance in gastric cancer.
  • H. Cho, K. Baek, Jiyun Yoo
  • Biology, Chemistry
    Biochemical and biophysical research…
  • 28 October 2011
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Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates multiorgan development in zebrafish
TLDR
Results indicated that Slc25a17 acts as a CoA transporter, involved in the maintenance of functional peroxisomes that are essential for the development of multiple organs during zebrafish embryogenesis.
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Gadd45b Mediates Fas-induced Apoptosis by Enhancing the Interaction between p38 and Retinoblastoma Tumor Suppressor*
TLDR
It is suggested that Gadd45b mediates p38-induced Rb phosphorylation by enhancing the interaction between p38 and Rb during Fas-induced apoptosis in murine hepatocytes.
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Proteomics-based strategy to delineate the molecular mechanisms of RhoGDI2-induced metastasis and drug resistance in gastric cancer.
TLDR
The mechanism by which RhoGDI2 promotes gastric cancer cell invasion and chemoresistance using two-dimensional gel electrophoresis (2-DE) is delineated using matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF-MS).
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