Inês Vaz Pinto

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OBJECTIVES Despite a decreasing mortality and morbidity in treated HIV-1 patients, highly active antiretroviral treatment (HAART) can still fail due to the development of drug resistance. Especially, multidrug-resistant viruses pose a threat to efficient therapy. We studied the changing prevalence of multidrug resistance (MDR) over time in a cohort of(More)
Methods The unit analysis was a person-regimen of 2 NRTI (NNRTI, PI/r) lasting ]90 days. Adherence was measured by the proportion of days covered using pharmacy refill data. The Wilcoxon rank-sum test was used to compare CNA, PNA and total non-adherence (TNA) in the following groups: STR vs its components (EFV TDF/FTC) and non-FDC vs FDC vs STR. The level(More)
INTRODUCTION Current Portuguese HIV treatment guidelines recommend initiating antiretroviral therapy with a regimen composed of two Nucleoside Reverse Transcriptase Inhibitors plus one Non-nucleoside Reverse Transcriptase Inhibitor (2NRTI+NNRTI) or two Nucleoside Reverse Transcriptase Inhibitors plus one boosted protease inhibitor (2NRTI+PI/r). Given the(More)
Methods Time to regimen switch (discontinuing at least one ARV) due to VF (two consecutive viral loads >50 cps/ml after viral suppression or 6-months unreached viral suppression), time to regimen switch due to any other reason and time to resistance development were calculated using survival analysis. Log-rank test for equality of survivor functions was(More)
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