Inês Vaz Pinto

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OBJECTIVES Despite a decreasing mortality and morbidity in treated HIV-1 patients, highly active antiretroviral treatment (HAART) can still fail due to the development of drug resistance. Especially, multidrug-resistant viruses pose a threat to efficient therapy. We studied the changing prevalence of multidrug resistance (MDR) over time in a cohort of(More)
Purpose of the study Fixed-dose combinations (FDCs) and single-tablet regimens (STRs) may reduce complete non-adherence (CNA) but also have the potential additional benefit of avoiding partial non-adherence (PNA) (some but not all drugs taken). We test this hypothesis and then estimate the impact of PNA-free regimen (STRs) on clinical and economic outcomes.(More)
Purpose of the study To compare ART initiation with 2NRTI+NNRTI versus 2NRTI+PI through a retrospective analysis and incorporate these results in a cost-effectiveness analysis. Methods Time to regimen switch (discontinuing at least one ARV) due to VF (two consecutive viral loads >50 cps/ml after viral suppression or 6-months unreached viral suppression),(More)
INTRODUCTION Current Portuguese HIV treatment guidelines recommend initiating antiretroviral therapy with a regimen composed of two Nucleoside Reverse Transcriptase Inhibitors plus one Non-nucleoside Reverse Transcriptase Inhibitor (2NRTI+NNRTI) or two Nucleoside Reverse Transcriptase Inhibitors plus one boosted protease inhibitor (2NRTI+PI/r). Given the(More)
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