Inês Chendo

Learn More
Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF signaling is thought to contribute to the pathogenesis of schizophrenia (SZ) especially in relation to cognitive deficits. Clozapine (CLZ) has been shown a beneficial effect on cognition in SZ in some studies and a detrimental effect in(More)
OBJECTIVE There are several models of staging in bipolar disorder (BD), but none has been validated. The aims of this study were to empirically investigate clinical variables that may be useful to classify patients in clusters according to stage and study the association with biomarkers as biological validators. METHOD This was a historical cohort study.(More)
OBJECTIVE Brain-derived neurotrophic factor (BDNF) is consistently associated with acute mood episodes in bipolar disorder, but there is a lack of longitudinal data to support this hypothesis. In this 16-week open-label clinical trial, we tested the predictive role of BDNF Val66Met polymorphism on serum BDNF levels and the relationship of serum BDNF and(More)
INTRODUCTION A growing body of evidence suggests that bipolar disorder (BD) is a progressive disease according to clinical, biochemical and neuroimaging findings. This study reviewed the literature on the relationship between specific biomarkers and BD stages. METHODS A comprehensive literature search of MEDLINE and PubMed was conducted to identify(More)
Electroconvulsive therapy (ECT) is an efficient, safe and even life saving treatment for several psychiatric disorders, namely depressive disorder, bipolar disorder and schizophrenia. Many were the doubts with it utilization, namely until the 1980s. After that it became more accepted with the publication of guidelines for many international associations of(More)
Onset of bipolar disorder (BD) in childhood is common and often associated with extraordinarily long delays to specific treatment. Perlis et al. in the STEP-BD study found that 66% of their cohort had onset in childhood or adolescence (until the age of 18) (Perlis et al., 2004). They also reported that early onset was associated with more comorbid substance(More)
UNLABELLED Medication compliance is one of the foremost problems affecting neuroleptic efficacy in psychiatric patients. It is a crucial point to dispone of useful instruments that allow us a fiable assessment of patients' medication adherence in order to plan more appropriate therapeutical interventions. The aim of our study was to validade the Portuguese(More)
INTRODUCTION Parkinson´s disease (PD) is a synucleinopathy that affects millions of people worldwide and leads to progressive disability. Psychosis is highly prevalent in PD patients and is associated with poor prognosis. Until April 2016, there were no licensed drugs available in the United States of America (USA) for the treatment of PD psychosis (PDP).(More)
Lack of insight into mental disorder is a frequent phenomenon in patients affected by a psychotic disorder and can be an important predicting factor involving the course of the disease mainly regarding compliance with treatment. The aim of the present study was to validate the Portuguese version of the Marková and Berrios Insight Scale, a self-report(More)
OBJECTIVES Staging models for medical diseases are widely used to guide treatment and prognosis. Bipolar disorder (BD) is a chronic condition and it is among the most disabling disorders in medicine. The staging model proposed by Kapczinski in 2009 presents four progressive clinical stages of BD. Our aim was to evaluate pharmacological maintenance treatment(More)