Inhibitor of DNA binding 1 (Id1) and 3 (Id3) genes have been related with the inhibition of cell differentiation, cell growth promotion and tumor metastasis. Recently, Id1 has been identified as an independent prognostic factor in patients with lung adenocarcinoma, regardless of the stage. Furthermore, Id1 may confer resistance to treatment (both,… (More)
Liver metastases appear in 20–30% of patients diagnosed with non-small cell lung cancer (NSCLC) and represent a poor prognosis feature of NSCLC and a possibly more treatment-resistant condition. Potential clinical outcome differences in NSCLC patients with liver metastases harboring molecular alterations in EGFR, KRAS and EML4-ALK genes are still to be… (More)
We studied whether thymidylate synthase (TS) genotype has an independent prognostic/predictive impact on a European population of advanced non-small cell lung cancer (NSCLC) patients receiving pemetrexed. Twenty-five patients treated with pemetrexed-based regimens were included. Genomic DNA was isolated prior to treatment. The variable number of tandem… (More)
— A finite element modeling of tire using Ansys is used to analyze the free vibration of radial pneumatic tires. The natural frequencies and mode shapes of pneumatic tires are investigated. The effects of some parameters such inflation pressure, tread pattern, ply-angles and thickness of belts on the natural frequency of tires are investigated.
In acoustic imaging practise, where two-dimensional area measurements are performed, spatial sampling is a little addressed subject. Especially aliasing due to high spatial sampling at short sensor distance with respect to the source of interest, is poorly discussed in open literature. This paper will discuss the theory behind optimal spatial sampling for… (More)