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Glucose promotion of GABA metabolism contributes to the stimulation of insulin secretion in β-cells.
We have demonstrated recently that branched-chain α-keto acid stimulation of insulin secretion is dependent on islet GABA (γ-aminobutyric acid) metabolism: GABA transamination to succinicExpand
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Branched-chain 2-oxoacid transamination increases GABA-shunt metabolism and insulin secretion in isolated islets.
We have previously shown that oxo-4-methylpentanoate promotes islet GABA (gamma-aminobutyric acid) metabolism and stimulates insulin secretion. The main aim of this work was to explore theExpand
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New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres.
New strategies for tacrolimus administration that conserve its immunosuppressive effect but avoiding fluctuations in tacrolimus circulating levels are needed. The aim was to analyze if subcutaneousExpand
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