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Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes
Ubiquitin (Ub) and ubiquitin-like proteins (Ubls) are conjugated to their targets by specific cascades involving three classes of enzymes, E1, E2, and E3. Each E1 adenylates the C terminus of its… Expand
The role of DNA bending in type IIA topoisomerase function
Type IIA topoisomerases control DNA supercoiling and separate newly replicated chromosomes using a complex DNA strand cleavage and passage mechanism. Structural and biochemical studies have shown… Expand
Distinct regions of the Escherichia coli ParC C-terminal domain are required for substrate discrimination by topoisomerase IV.
Type IIA DNA topoisomerases are essential enzymes that use ATP to maintain chromosome supercoiling and remove links between sister chromosomes. In Escherichia coli, the type IIA topoisomerase topo IV… Expand
- Jihyun Shim, Yonguk Shin, Imsang Lee, S. Kim
- Medicine, Biology
- Advances in biochemical engineering/biotechnology
L-Methionine has been used in various industrial applications such as the production of feed and food additives and has been used as a raw material for medical supplies and drugs. It functions not… Expand
Insights into ubiquitin activation and transfer to E2 from the structure of the Uba1-ubiquitin complex
- Imsang Lee
- 1 August 2007
Stony Brook University Libraries. SBU Graduate School in Biochemistry and Structural Biology. Lawrence Martin (Dean of Graduate School), Hermann Schindelin, Ph.D. Advisor Professor,… Expand