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1. Recent evidence from studies in mice lacking the opioid receptor-like (ORL-1) receptor and from experiments using antibodies raised against orphanin FQ/nociceptin (OFQ/N) suggest that this peptide may be involved in morphine tolerance. In the present study we sought to investigate if administration of exogenous OFQ/N would modulate the development of(More)
The extent to which different kinds of organisms have adapted to environmental temperature regimes is central to understanding how they respond to climate change. The Scholander-Irving (S-I) model of heat transfer lays the foundation for explaining how endothermic birds and mammals maintain their high, relatively constant body temperatures in the face of(More)
RATIONALE Orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the opioid receptor-like (ORL-1) receptor, shows similarities to dynorphin A (1-17) in structure and functions. Dynorphin and other kappa opioid receptor agonists have been shown to block cocaine sensitization. OBJECTIVE The present study was designed to examine the ability of OFQ/N to(More)
This paper starts the investigation on dynamic algorithms for solving games that are played on finite graphs. The dynamic game determinacy problem calls for finding efficient algorithms that decide the winner of the game when the underlying graph undergoes repeated modifications. In this paper, we focus on turn-based reachability games. We provide an(More)
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