Imran H. Khan

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BACKGROUND The primate lentiviruses, human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), encode a conserved accessory gene product, Nef. In vivo, Nef is important for the maintenance of high virus loads and progression to AIDS in SIV-infected adult rhesus macaques. In tissue culture cells expressing Nef,(More)
Tuberculosis (TB) is a serious global disease. The fatality rate attributed to TB is among the highest of infectious diseases, with approximately 2 million deaths occurring per year worldwide. Identification of individuals infected with Mycobacterium tuberculosis and screening of their immediate contacts is crucial for controlling the spread of TB. Current(More)
Prostate cancer (PCa) has been linked to fat intake, but the effects of both different dietary fat levels and types remain inconsistent and incompletely characterised. The effects on PCa in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model of an elevated fat (20 % of energy as fat) diet containing 155 g of whole walnuts were compared(More)
PRESENILIN1 (PSEN1) is the major locus for mutations causing familial Alzheimer's disease (FAD) and is also mutated in Pick disease of brain, familial acne inversa and dilated cardiomyopathy. It is a critical facilitator of Notch signalling and many other signalling pathways and protein cleavage events including production of the Amyloidβ (Aβ) peptide from(More)
Quality of Experience (QoE) is emerging as the holy grail of human-centric multimedia services. QoE is a multi-disciplinary field based on social psychology, cognitive science, economics and engineering science, focused on understanding overall human quality of experience requirements. QoE has been viewed as the pivotal set of metrics in determining the(More)
A specific targeting modality for hepatocellular carcinoma (HCC) could ideally encompass a liver cell specific delivery system of a transcriptional unit that is active only in neoplastic cells. Sendai virosomes, derived from Sendai viral envelopes, home to hepatocytes based on the liver specific expression of asialoglycoprotein receptors (ASGPRs) which are(More)
As the enormous amount of data is generated with a high speed a new era of data processing age has started `The Big Data Processing'. Big Data deals with the data that have high Volume, high Velocity, high Variety and high Veracity also known as 4V's of Big Data. Managing Big data with the traditions systems are not possible due to the 4V's property of Big(More)
BACKGROUND Delay in diagnosis and treatment of tuberculosis (TB) may enhance the chances of morbidity and mortality and play a key role in continuous transmission of the bacilli. The objective of this study was to describe health care seeking behavior of suspected TB patients and initial diagnostic work up prior to consultation and diagnosis at National TB(More)
MicroRNAs (miRNAs) have been found to be dysregulated in epithelial ovarian cancer (EOC) and may function as either tumor suppressor genes (TSGs) or as oncogenes. Hypermethylation of miRNA silences the tumour suppressive function of a miRNA or hypermethylation of a TSG regulating that miRNA (or vice versa) leads to its loss of function. The present study(More)
An artificial limb is a type of prosthesis that replaces a missing extremity, such as arms or legs. The type of artificial limb required is determined by the availability of the left over stump after amputation. The main problem faced by the patients after amputation or paralysis is muscle atrophy caused due to non-functionality of the stump. The limited(More)