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The retinal pigment epithelium (RPE) maintains retinal function as the metabolic gatekeeper between photoreceptors (PRs) and the choriocapillaries. The RPE and Bruch's membrane (BM) suffer cumulative damage over lifetime, which is thought to induce age-related macular degeneration (AMD) in susceptible individuals. Unlike palliative pharmacologic treatments,(More)
AIM The current accepted standard treatment for neovascular age-related macular degeneration (AMD) consists of antivascular endothelial growth factor agents including ranibizumab and bevacizumab. The aim of the study was to examine whether bevacizumab is inferior to ranibizumab with respect to maintaining/improving visual acuity. METHODS In this(More)
PURPOSE To compare the state of the posterior vitreous in exudative age-related macular degeneration (AMD) with eyes with nonexudative AMD and controls. DESIGN Prospective, observational case series. METHODS B-scan ultrasonography and optical coherence tomography (OCT) were performed in 163 eyes from 82 subjects older than 55 years, 50 eyes with(More)
AIMS To evaluate the outcome after two types of retinal pigment epithelium (RPE) transplantation techniques. METHODS Fourteen consecutive patients with advanced exudative age-related macular degeneration (AMD) were randomly assigned to RPE-choroid sheet transplantation (group 1) or RPE cell-suspension transplantation (group 2). Outcome measures included(More)
PURPOSE To examine whether the encouraging functional results one year after photodynamic therapy (PDT) can be maintained up to three years. DESIGN Prospective interventional case series. METHODS Highly myopic eyes that had been treated with PDT for subfoveal choroidal neovascularization and had been observed at least 36 months were included. Distance(More)
PURPOSE To describe the indications, surgical technique, and clinical results of 14 eyes in 13 patients with age-related macular degeneration and foveal choroidal neovascularization, in which subretinal surgery was combined with simultaneous transplantation of autologous retinal pigment epithelial cells. METHODS Between March 1999 and February 2000, in a(More)
In the center of the fovea centralis of retinas of three cynomolgus monkeys, one baboon and one male human, the external limiting membrane contains circumscribed areas in which zonulae adherentes are lacking between cone inner segments and apices of Müller cells. These discontinuities of the external limiting membrane begin about 300 microns from the(More)
PURPOSE To present the outcome of a consecutive series of patients who had foveal choroidal neovascularization (fCNV) in age-related macular degeneration (AMD) and were treated with subretinal surgery combined with simultaneous transplantation of autologous retinal pigment epithelial (RPE) cells. METHODS Patients with fCNV who were not eligible for laser(More)
PURPOSE To evaluate the potential benefit of vitrectomy in eyes with persistent diffuse macular edema. DESIGN Prospective randomized comparative clinical trial. METHODS Eyes with diffuse diabetic macular edema for 6 to 18 months, an attached posterior hyaloid, and grid laser photocoagulation performed at least 4 months before were included. Patients(More)
By using electron microscopy to study the quantitative morphology of the retina, it was possible to determine the spatial density of all principal retinal cells at a defined retinal location. In two retinas of cynomolgus monkeys at a position of 30 degrees nasal of the fovea centralis, the following cell densities were determined from composite electron(More)