Illerhaus G Klapper

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Bacterial biofilms, while made up of microbial-scale objects, also function as meso- and macroscale materials. In particular, macro-scale material properties determine how biofilms respond to large-scale mechanical stresses, e.g. fluid shear. Viscoelastic and other constitutive properties influence biomass structure (through growth and fluid shear stresses)(More)
Biofilms, sticky conglomerations of microorganisms and extracellular polymers, are among the Earth's most common life forms. One component for their survival is an ability to withstand external mechanical stress. Measurements indicate that biofilm elastic relaxation times are approximately the same (about 18 min) over a wide sample of biofilms though other(More)
A mathematical model describing the constitutive properties of biofilms is required for predicting biofilm deformation, failure, and detachment in response to mechanical forces. Laboratory observations indicate that biofilms are viscoelastic materials. Likewise, current knowledge of biofilm internal structure suggests modeling biofilms as associated polymer(More)
It has been known for many years that small fractions of persister cells resist killing in many bacterial colony-antimicrobial confrontations. These persisters are not believed to be mutants. Rather it has been hypothesized that they are phenotypic variants. Current models allow cells to switch in and out of the persister phenotype. Here, a different(More)
Biofilm structure plays an important role in biofilm function and control. It is thus important to determine the extent to which mechanics may determine structure in biofilms. We consider a generic qualitative constitutive description of biofilm incorporating as assumptions a small number of fundamental physical properties of biofilm viscoelasticity and(More)
In contrast to their name, biofilms are not always flat and homogeneous but instead often exhibit complex structural heterogeneity. It has been suggested that nonhomogeneous geometry is selected in order to increase biofilm growth rate. A previous study (Dockery and Klapper (2002) SIAM J. Appl. Math., 62, 853-869) of a model biofilm system in a static bulk(More)
A set of dynamical equations are derived for a slender tube of isolated magnetic ux generalizing a model due to Spruit. The tube is assumed to consist of eld lines which twist about the tube's axis at some rate q. The equations describe the evolution of the axis and the evolution of the twist. They include the interaction between twist and motions of the(More)
We present a comparison of the continuous versus discrete models of large-scale DNA conformation, focusing on issues of relevance to molecular dynamics. Starting from conventional expressions for elastic potential energy, we derive elastic dynamic equations in terms of Cartesian coordinates of the helical axis curve, together with a twist function(More)
  • Journalbeiträge Berod, Heinemann C, Bürgel, B Friesland, M Koch, Manns Mp +75 others
  • 2013
(2011) PI3K deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome. (2011) Hepatitis C virus enters human peripheral neuroblastoma cells-evidence for extra-hepatic cells sustaining hepatitis C virus penetration. Presence and seeding activity of pathological prion protein (PrP(TSE)) in skeletal muscles(More)
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