Learn More
Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately predict drug toxicity. In this study, we present a multi-organ-chip capable of maintaining 3D tissues derived from cell lines, primary cells and biopsies of various human organs. We designed a(More)
Substantial progress has been achieved over the last few decades in the development of skin equivalents to model the skin as an organ. However, their static culture still limits the emulation of essential physiological properties crucial for toxicity testing and compound screening. Here, we describe a dynamically perfused chip-based bioreactor platform(More)
Across many tissues and organs, the ability to create an organoid, the smallest functional unit of an organ, in vitro is the key both to tissue engineering and preclinical testing regimes. The hair follicle is an organoid that has been much studied based on its ability to grow quickly and to regenerate after trauma. But hair follicle formation in vitro has(More)
Dynamic miniaturized human multi-micro-organ bioreactor systems are envisaged as a possible solution for the embarrassing gap of predictive substance testing prior to human exposure. A rational approach was applied to simulate and design dynamic long-term cultures of the smallest possible functional human organ units, human "micro-organoids", on a chip the(More)
Introduction The ability to create an organoid, the smallest functional unit of an organ, in vitro across many human tissues and organs is the key to both efficient transplant generation and predictive preclinical testing regimes. The hair follicle is an organoid that has been much studied based on its ability to grow quickly and to regenerate after trauma.(More)
Background Enormous efforts have been made to develop circulation systems for physiological nutrient supply and waste removal of in vitro cultured tissues. These developments are aiming for in vitro generation of organ equivalents such as liver, lymph nodes and lung or even multi-organ systems for substance testing, research on organ regenera-tion or(More)
Background and novelty In recent decades, substantial progress to mimic structures and complex functions of human skin in the form of skin equivalents has been achieved. Different approaches to generate functional skin models were made possible by the use of improved bioreactor technologies and advanced tissue engineering. Although various forms of skin(More)
Background Current in vitro and animal tests for drug development are failing to emulate the organ complexity of the human body and, therefore, to accurately predict drug toxicity. In this study, we present a self-contained, bior-eactor based human in vitro tissue culture test system aiming to support predictive substance testing at relevant throughput. We(More)
  • 1