Pro-inflammatory cytokines-in particular tumor necrosis factor (TNF)-alpha-play an important role in pain and hyperalgesia. The stimuli inducing TNF-alpha release in humans and the time course of this release are largely unknown. We performed dermal microdialysis in healthy subjects (n=36) during three experimental conditions: The first condition (control)… (More)
The aim of the study was to use a battery of biotests composed of producers (Selenastrum capricornutum, Sorghum saccharatum, Lepidium sativum, and Sinapis alba), consumers (Thamnocephalus platyurus), and decomposers (Tetrahymena thermophila) to evaluate the toxicity of snowmelt and winter storm water samples. The toxicity of the samples collected in the… (More)
wurde die Studie durch die Beiräte der Fach-gruppen " Zellkulturtechnologie " und " Medi-zinische Biotechnologie " der DECHEMA e. V., auf schweizerischer Seite vom nationalen Kompetenzzentrum TEDD (Tissue Engineering for Drug Development and Substance Testing) getragen.
Background Enormous efforts have been made to develop circulation systems for physiological nutrient supply and waste removal of in vitro cultured tissues. These developments are aiming for in vitro generation of organ equivalents such as liver, lymph nodes and lung or even multi-organ systems for substance testing, research on organ regenera-tion or… (More)
Background and novelty In recent decades, substantial progress to mimic structures and complex functions of human skin in the form of skin equivalents has been achieved. Different approaches to generate functional skin models were made possible by the use of improved bioreactor technologies and advanced tissue engineering. Although various forms of skin… (More)
Background Current in vitro and animal tests for drug development are failing to emulate the organ complexity of the human body and, therefore, to accurately predict drug toxicity. In this study, we present a self-contained, bior-eactor based human in vitro tissue culture test system aiming to support predictive substance testing at relevant throughput. We… (More)
Direct loudness scaling has been known as an audiological tool for about four decades. Although numerous publications have shown its clinical importance, loudness scaling has not been used in audiology and hearing aid fitting until now. This might be due to the lack of audiometers equipped with loudness scaling devices as well as missing evidence for its… (More)