Ilinca Stanciulescu

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The simulation of complex systems is important in many fields of science and in real-world applications. Such systems are composed of many interacting subsystems. There might exist different software packages for simulating the individual subsystems and co-simulation refers to the simultaneous execution of multiple interacting subsystem simulators.(More)
Poly(ethylene glycol) diacrylate (PEGDA) hydrogels can be potentially used as scaffold material for tissue engineered heart valves (TEHVs) due to their good biocompatibility and biomechanical tunability. The photolithographic patterning technique is an effective approach to pattern PEGDA hydrogels to mimic the mechanical behavior of native biological(More)
Arterial walls typically have a heterogeneous structure with three different layers (intima, media, and adventitia). Each layer can be modeled as a fiber-reinforced material with two families of relatively stiff collagenous fibers symmetrically arranged within an isotropic soft ground matrix. In this paper, we present two different modeling approaches, the(More)
This paper presents a computational framework to simulate the mechanical behavior of fibrous biomaterials with randomly distributed fiber networks. A random walk algorithm is implemented to generate the synthetic fiber network in 2D used in simulations. The embedded fiber approach is then adopted to model the fibers as embedded truss elements in the ground(More)
Layered constructs from poly(ethylene glycol) (PEG) hydrogels and chicken eggshell membranes (ESMs) are fabricated, which can be further cross-linked by glutaraldehyde (GA) to form GA-PEG-ESM composites. Our results indicate that ESMs composed of protein fibrous networks show elastic moduli ∼3.3-5.0 MPa and elongation percentages ∼47-56%, close to human(More)
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