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Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes
Through phylogenetic genome comparison, this work identifies here two genes that share with urate oxidase a common history of loss or gain events and shows that the two proteins encoded by mouse genes catalyze two consecutive steps following urate oxidation to 5-hydroxyisourate (HIU): hydrolysis of HIU and decarboxylation of OHCU to give S-allantoin. Expand
Structure of zebra fish HIUase: insights into evolution of an enzyme to a hormone transporter.
The crystal structure of zebra fish HIUase in two different crystal forms is reported, showing a highly conserved scaffold, harbouring distinct functional sites located in the same regions of the two vertebrate proteins. Expand
Effect of cold plasma treatment on physico-chemical parameters and antioxidant activity of minimally processed kiwifruit
Abstract The efficacy of atmospheric plasma treatment on microbial decontamination of different kinds of food products is already known. Recently, new applications of this innovative technology haveExpand
EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism
It is demonstrated that EGCG antagonizes BZM toxicity by exacerbating the activation of autophagy, which in turn mitigates ER stress and reduces CHOP up-regulation, finally protecting PC3 cells from cell death. Expand
Ligand Binding and Structural Analysis of a Human Putative Cellular Retinol-binding Protein*
The results indicate that human CRBP IV belongs to a clearly distinct CRBP subfamily and suggest a relatively different mode of retinol binding for this binding protein. Expand
Logical Identification of an Allantoinase Analog (puuE) Recruited from Polysaccharide Deacetylases*
It is shown that an alternative allantoinase gene (puuE) can be precisely identified by analyzing its logic relationship with three other genes of the pathway by providing a structural rationale for the shifting of substrate specificity that occurred during evolution. Expand
Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria.
NMR evidence is reported that the true product of the AAH reaction is S-ureidoglycine, a nonstandard alpha-amino acid that spontaneously releases ammonia in vitro, strengthening the basis for the known sensitivity of the ureide pathway to Mn availability and suggesting a further rationale for the active transport of Mn in the endoplasmic reticulum of plant cells. Expand
An aminotransferase branch point connects purine catabolism to amino acid recycling.
Structural comparison and mutational analysis suggest a molecular rationale for the functional divergence between UGXT and peroxisomal alanine-glyoxylate aminotransferase, a fundamental enzyme for glyoxylates detoxification in humans. Expand
Distinctive binding and structural properties of piscine transthyretin
Some amino acid differences in discrete regions of sea bream TTR appear to be responsible for the lack of protein–protein recognition, providing evidence for the crucial role played by a limited number of residues in the interaction between RBP and TTR. Expand
Systematic review on strength training in Parkinson’s disease: an unsolved question
Investigation of the effectiveness of strength training, performed against a different resistance from body weight, in improving motor and nonmotor symptoms in patients with Parkinson’s disease found it difficult to establish a correlation between strength training and the improvements made. Expand