Ileana Paul

Learn More
Direct pharmacological targeting of the anti-apoptotic B-cell lymphoma-2 (BCL-2) family is an attractive therapeutic strategy for treating cancer. Obatoclax is a pan-BCL-2 family inhibitor currently in clinical development. Here we show that, although obatoclax can induce mitochondrial apoptosis dependent on BCL-2 associated x protein/BCL-2 antagonist(More)
Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression of FLIP, which blocks the extrinsic apoptotic pathway by inhibiting caspase-8 activation, has been identified in various cancers. We investigated FLIP and procaspase-8 expression in NSCLC and the effect of HDAC inhibitors on FLIP expression,(More)
Failure to efficiently induce apoptosis contributes to cisplatin resistance in non-small-cell lung cancer (NSCLC). Although BCL-2-associated X protein (BAX) and BCL-2 antagonist killer (BAK) are critical regulators of the mitochondrial apoptosis pathway, their requirement has not been robustly established in relation to cisplatin. Here, we show that(More)
1. Introduction The semantic property of definiteness is signalled in a variety of ways cross-linguistically. In English, the definiteness of NPs is for the most part signalled by articles like the and a. But other options are available when a broader cross-linguistic perspective is taken. This paper focuses on how the definiteness of NPs is signalled in(More)
This paper explores the distribution of Free Choice Items (FCI) and Negative Polarity Items (NPI) in Malagasy. Both FCIs and NPIs in Malagasy are syntactically complex: they are expressed by disjunctions of wh-words. It is shown that this morphosyntactic structure directly reflects their semantics. In other words, FCIs and NPIs are semantically as well as(More)
  • 1