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Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core.
TLDR
The current state of knowledge of the biogenesis and assembly of the eukaryotic COX catalytic core is reviewed and the degree of conservation of the players and mechanisms operating from yeast to human is discussed. Expand
Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process.
TLDR
The present knowledge about the different regulatory checkpoints in COX assembly and the dynamic relationships between the different factors involved in the process are described and analyzed. Expand
Cytochrome c oxidase biogenesis: New levels of regulation
TLDR
COX assembly and stability of the fully assembled enzyme depend on the presence in the mitochondrial compartments of two partners of the oxidative phosphorylation system, the mobile electron carrier cytochrome c and the mitochondrial ATPase. Expand
Suppression mechanisms of COX assembly defects in yeast and human: insights into the COX assembly process.
TLDR
The isolation and characterization of genetic and metabolic suppressors of COX assembly defects have become a profitable strategy to gain insight into their functions and the pathways in which they operate and have the potential to provide useful information for devising therapeutic approaches to combat human disorders associated with COX deficiency. Expand
Synthesis of cytochrome c oxidase subunit 1 is translationally downregulated in the absence of functional F1F0-ATP synthase.
TLDR
These findings imply that fully assembled ATPase and its proton pumping function are both required for COX biogenesis in yeast and mammalian cells through a mechanism independent of Cox1p synthesis. Expand
Response to genistein: assaying the activation status and chemotaxis efficacy of isolated neutrophils.
TLDR
A "genistein assay" is developed to directly predict PMN status after each isolation and has not only revealed new insights into the mechanisms of PMN activation and assisted in functional assays, but it has provided a method that can be mastered by both inexperienced and experienced researchers to assay isolated PMN and thus avoid using inconsistent cells in their experiments. Expand
SIRPβ1 Is Expressed as a Disulfide-linked Homodimer in Leukocytes and Positively Regulates Neutrophil Transepithelial Migration*
TLDR
Functional studies revealed that antibody-mediated ligation of SIRPβ1 enhanced formylmethionylleucylphenylalanine-driven PMN transepithelial migration and their potential role(s) in fine-tuning responses to inflammatory stimuli. Expand
Control of Secondary Granule Release in Neutrophils by Ral GTPase*
TLDR
It is demonstrated that Ral is a critical regulator in PMN that specifically controls secondary granule release during PMN response to chemoattractant stimulation. Expand
SIRP1 Is Expressed as a Disulfide-linked Homodimer in Leukocytes and Positively Regulates Neutrophil
TLDR
Functional studies revealed that antibody-mediated ligation of SIRP 1 enhanced formylmethionylleucylphenylalanine-drivenPMN transepithelial migration and provided new insights into the structure and function of S IRPs in leukocytes and their potential role(s) in fine-tuningresponses to inflammatory stimuli. Expand
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