Ildy M. Katona

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The binding of immunoglobulin E (IgE) to high affinity IgE receptors (Fc ⑀ RI) expressed on the surface of mast cells primes these cells to secrete, upon subsequent exposure to specific an-tigen, a panel of proinflammatory mediators, which includes cytokines that can also have im-munoregulatory activities. This IgE-and antigen-specific mast cell activation(More)
The cytokine interleukin (IL) 12 stimulates T cell and natural killer cell production of interferon (IFN) gamma and inhibits T cell production of IL-4. We investigated the effects of IL-12 on cytokine gene expression, immunoglobulin (Ig)E, mucosal mast cell, and eosinophil responses, and the course of infection in mice inoculated with the nematode parasite(More)
The binding of immunoglobulin E (IgE) to high affinity IgE receptors (Fc(epsilon)RI) expressed on the surface of mast cells primes these cells to secrete, upon subsequent exposure to specific antigen, a panel of proinflammatory mediators, which includes cytokines that can also have immunoregulatory activities. This IgE- and antigen-specific mast cell(More)
Antigens and infectious agents that stimulate interferon alpha(IFN-alpha) production in mice induce antibody responses that are predominantly of the immunoglobulin (Ig)G2a isotype and contain little or no IgE. This suggested the possibility that IFN-alpha might have a role in directing Ig isotype selection. Consistent with this possibility, we have found(More)
Antigens and infectious agents that stimulate interferon ot(IFN-t~) production in mice induce antibody responses that are predominantly of the immunoglobulin (Ig)G2a isotype and contain little or no IgE. This suggested the possibility that IFN-ot might have a role in directing Ig isotype selection. Consistent with this possibility, we have found that(More)
Introduction Juvenile localized scleroderma (JLS) is a childhood condition characterized by thickening of the skin. A variety of clinical subtypes have been described , differentiated by the size, shape, and location of skin involvement as well as the presence or absence of extra-cutaneous manifestations. These
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