Ilaria Carriero

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OBJECTIVE Crystalline NPH insulin comes in a two-phase solution with either a solvent or a rapid-acting insulin (in premixed formulations) and needs adequate mixing for complete resuspension before injection. The aim of this study was to establish pharmacokinetics (PK) and pharmacodynamics (PD) after injection of appropriately resuspended versus(More)
PK and PDwere assessed after subcutaneous injection of NPH insulin 0.35 units/kg at steady-state by pen either resuspended (R+, tipping of insulin pen 20 times) or nonresuspended (penmaintained in fixed position either horizontally [Rhorizontal] or vertically with tip up [Rup] or tip down [Rdown]). Eleven subjectswith type 1 diabetes (age 31.56 12 years,(More)
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