Ikuyo Motokawa

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INTRODUCTION Breast cancer is a leading cause of cancer-related death in women worldwide, and its metastasis is a major cause of disease mortality. Therefore, identification of the mechanisms underlying breast cancer metastasis is crucial for the development of therapeutic and diagnostic strategies. Our recent study of immunodeficient female mice(More)
Bone metastasis of breast cancer cells is a major concern, as it causes increased morbidity and mortality in patients. Bone tissue-derived CXCL12 preferentially recruits breast cancer cells expressing CXCR4 to bone metastatic sites. Thus, understanding how CXCR4 expression is regulated in breast cancer cells could suggest approaches to decrease bone(More)
Angiopoietin-like protein 2 (ANGPTL2) plays an important role in inflammatory carcinogenesis and tumor metastasis by activating tumor angiogenesis and tumor cell chemotaxis and invasiveness. However, it is unclear whether ANGPTL2 expression has an effect on tumor cell survival. Here, we explored that possibility by determining whether ANGPTL2 expression(More)
Angiopoietin-like protein 2 (ANGPTL2) is a chronic inflammatory mediator that, when deregulated, is associated with various pathologies. However, little is known about its activity in lung. To assess a possible lung function, we generated a rabbit monoclonal antibody that specifically recognizes mouse ANGPTL2 and then evaluated protein expression in mouse(More)
“T.M., E.M. and O.Y. developed the initial concept. T.M., E.M. and O.Y. designed experiments. T.M., O.H. and T.K. performed experiments and analyzed data. M.S.M. and I.M. performed RNA sequencing. Y.Y. analyzed clinical data. T.M., M.E. and O.Y. co-wrote the manuscript. T.N., H.T., H.I., M.Y., K.M., J.M., H.H., I.M. and K.T. reviewed the manuscript. H.I.(More)
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