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Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.

• Kazuo Yasumoto, Keiichi Koizumi, +9 authors Ikuo Saiki
• Cancer research
• 2006

Peritoneal carcinomatosis is a frequent cause of death in patients with advanced gastric carcinoma. Because chemokines are now considered to play an important role in the metastasis of various… (More)

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.

• Hiroaki Sakurai, Shunsuke Suzuki, +5 authors Ikuo Saiki
• The Journal of biological chemistry
• 2003

The activation of NF-kappaB has been shown to be regulated by multiple phosphorylations of IkappaBs and the NF-kappaB p65 subunit. Here, we characterized the intracellular signaling pathway leading… (More)

Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex…

• Pattama Singhirunnusorn, Shunsuke Suzuki, Noritaka Kawasaki, Ikuo Saiki, Hiroaki Sakurai
• The Journal of biological chemistry
• 2005

Transforming growth factor-beta-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase has been shown to be activated by cellular stresses including tumor necrosis factor-alpha… (More)

Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng.

• Mami Mochizuki, Yung Choon Yoo, +5 authors Ichiro Azuma
• Biological & pharmaceutical bulletin
• 1995

We examined the inhibitory effect of two saponin preparations from Red ginseng, 20(R)- and 20(S)-ginsenoside-Rg3, in comparison with that of ginsenoside-Rb2, on lung metastasis produced by two highly… (More)

Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide.

• Yumiko Hayakawa, Kazuyoshi Takeda, +5 authors Ko Okumura
• European journal of immunology
• 2001

The glycolipid alpha -galactosylceramide (alpha -GalCer), which is presented by CD1d and specifically activates Valpha 14 NKT cells, exerts a potent anti-metastatic effect when administered in vivo.… (More)

CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and…

• Yasufumi Katagiri, Jonathan Sleeman, +10 authors Toshimitsu Uede
• Cancer research
• 1999

The expression of osteopontin (OPN), CD44 variants, and integrins has been correlated with tumorigenesis and metastasis. Here we show that these proteins cooperate to enhance cell motility. First, we… (More)

Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways.

• Yumiko Hayakawa, Kazuyoshi Takeda, H. Yagita, Luc Van Kaer, Ikuo Saiki, Ko Okumura
• Journal of immunology
• 2001

Valpha14 NKT cells produce large amounts of IFN-gamma and IL-4 upon recognition of their specific ligand alpha-galactosylceramide (alpha-GalCer) by their invariant TCR. We show here that NKT cells… (More)

Immunological activity of chitin and its derivatives.

• Kazumi Nishimura, Susumu Nishimura, Nobuyuki Nishi, Ikuo Saiki, Seiichi Tokura, Ichiro Azuma
• Vaccine
• 1984

The effect of chitin and its derivatives on the activation of peritoneal macrophages in vivo, on the suppression of tumour growth in syngeneic mice and on the protection of the host against bacterial… (More)

Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation.

• Ikuo Saiki, Hideji Fujii, +4 authors Ichiro Azuma
• International journal of cancer
• 1993

We have investigated the effect of monoclonal antibodies (MAbs) specific for aminopeptidase N/CD13 on the invasion of human metastatic tumor cells into reconstituted basement membrane (Matrigel). The… (More)

High-Level Expression of Chemokine CXCL16 by Tumor Cells Correlates with a Good Prognosis and Increased Tumor-Infiltrating Lymphocytes in Colorectal Cancer

• Shozo Hojo, Keiichi Koizumi, +11 authors Ikuo Saiki
• Cancer research
• 2007

CXCL16 is a new member of the chemokine superfamily, which exists in a transmembrane as well as a soluble form. Its receptor CXCR6 is detected on CD4(+) T cells, CD8(+) T cells, and natural killer T… (More)

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