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Descending pathways from activated locus coeruleus/subcoeruleus following unilateral hindpaw inflammation in the rat
We have previously shown that the descending pathways from the locus coeruleus (LC)/subcoeruleus (SC) to the spinal cord are activated during peripheral inflammation, and that activation of thisExpand
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Spinal pathways mediating coeruleospinal antinociception in the rat
In a previous study, we showed in rats that axons of some locus coeruleus/subcoeruleus (LC/SC) neurons involved in coeruleospinal modulation of nociception descend through the ipsilateral side of theExpand
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Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.
One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex.Expand
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Antiangiogenic activity of hypoxylonol C.
Hypoxylonol C (1), isolated from the inedible mushroom Hypoxylon truncatum, exhibited inhibitory activities against the migration and tube formation of HUVECs. A cDNA microarray analysis wasExpand
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BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.
In BRAF-mutated melanoma cells, the BRAF inhibitor, vemurafenib, induces phosphorylation of eukaryotic initiation factor 2α (eIF2α) and subsequent induction of activating transcription factor 4Expand
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Abstract 1893: The effect of kinase signaling for miR-205 regulation in gefitinib-resistant lung cancer cell lines
Lung cancer is the leading cause of cancer related death in the world. Platinum-based combination regimen or molecular target drugs, such as EGFR tyrosine kinase inhibitors (EGFR-TKIs) and ALKExpand
Abstract 4658: Activation mechanisms of Integrated Stress Response by inhibition of oncogenic BRAF in melanoma cell lines
The eIF2α-ATF4 signaling pathway termed “Integrated stress response (ISR)” plays an important role in protecting cells against various cellular stresses such as deprivation of glucose and aminoExpand
GZD824 inhibits GCN2 and sensitizes cancer cells to amino acid starvation stress.
Eukaryotic initiation factor 2α kinase general control non-derepressible 2 (GCN2) drives cellular adaptation to amino acid limitation by activating the integrated stress response that inducesExpand