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Descending pathways from activated locus coeruleus/subcoeruleus following unilateral hindpaw inflammation in the rat
- M. Maeda, M. Tsuruoka, B. Hayashi, Ikuko Nagasawa, Tomio Inoue
- MedicineBrain Research Bulletin
- 16 March 2009
The development of hyperalgesia following the induction of unilateral hindpaw inflammation was compared between rats with either bilateral or unilateral lesions of the LC/SC and rats with a sham operation, and the result suggests that in theLC/SC both ipsilateral and contralateral to the inflamed paw, only neurons which project to the dorsal horn ipsilaterally were activated following peripheral inflammation.
Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.
- Ikuko Nagasawa, Akira Kaneko, +4 authors K. Koyama
- Medicine, ChemistryJournal of natural products
- 6 March 2014
In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells, possibly contributes to their antiangiogenesis activity.
Spinal pathways mediating coeruleospinal antinociception in the rat
- M. Tsuruoka, M. Maeda, Ikuko Nagasawa, Tomio Inoue
- Medicine, ChemistryNeuroscience Letters
- 27 May 2004
The results suggest that interruption of descending inhibition from the LC/SC produced by the VLF transections is due to the blockage of axons descending in the ventrolateral quadrant of the spinal cord, but not in the dorsolateral Quadrant.
Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.
- Ikuko Nagasawa, M. Muroi, +4 authors H. Osada
- Medicine, BiologyCell chemical biology
- 29 November 2019
A modified method by combining the CETSA and proteomics analysis based on 2D gel electrophoresis, namely 2DE-CETSA, to identify the thermal stability-shifted proteins by binding with a new compound is developed, applicable for identification of target compounds discovered by phenotypic screening.
Antiangiogenic activity of hypoxylonol C.
- M. Fukai, Toshihiro Suzuki, Ikuko Nagasawa, K. Kinoshita, Kunio Takahashi, K. Koyama
- Biology, MedicineJournal of natural products
- 25 April 2014
Cell cycle arrest and suppression of adhesion molecule expression might be plausible mechanisms of actions for the antiangiogenic activity of hypoxylonol C (1) in HUVECs.
BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.
- Ikuko Nagasawa, Kazuhiro Kunimasa, Satomi Tsukahara, A. Tomida
- Chemistry, MedicineBiochemical and biophysical research…
- 22 January 2017
It is shown that in response to vemurafenib, BRAF-mutated melanoma and colorectal cancer cells rapidly induced the ISR as a cytoprotective mechanism through activation of general control nonderepressible 2 (GCN2), an eIF2α kinase sensing amino acid levels, providing an insight into the development of drug resistance.
GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress
- Y. Kato, Kazuhiro Kunimasa, +5 authors A. Tomida
- Medicine, ChemistryMolecular Pharmacology
- 8 October 2020
It is found that a multikinase inhibitor, GZD824, which was identified using a cell-based assay with ATF4 immunostaining, inhibited the GCN2 pathway in cancer cells and sensitized certain cancer cells to amino acid starvation stress similarly to ATF4 knockdown.
A Parallel Cooperation Model for Natural Language Processing
Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy
- Ikuko Nagasawa, Masaru Koido, Yuri Tani, Satomi Tsukahara, Kazuhiro Kunimasa, A. Tomida
- Biology, MedicineiScience
- 31 March 2020
It is shown that oncogenic BRAF plays an essential role in the induction of ATF4 following the activation of general control non-derepressible 2 (GCN2) kinase during nutrient stress and BRAF-targeted, therapeutic stress and a chemical compound is identified that prevents BRAF inhibitor-induced activation of the GCN2-ATF4 pathway and produces synergistic cell killing with BRAF inhibitors.
Abstract 1893: The effect of kinase signaling for miR-205 regulation in gefitinib-resistant lung cancer cell lines
This study performs characterization of gefitinib resistant cell lines and suggests that alterations of kinase signals are more effective for miR-205 regulation than protein expression of target molecule itself, such as ErbB3.