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Descending pathways from activated locus coeruleus/subcoeruleus following unilateral hindpaw inflammation in the rat
TLDR
The development of hyperalgesia following the induction of unilateral hindpaw inflammation was compared between rats with either bilateral or unilateral lesions of the LC/SC and rats with a sham operation, and the result suggests that in theLC/SC both ipsilateral and contralateral to the inflamed paw, only neurons which project to the dorsal horn ipsilaterally were activated following peripheral inflammation.
Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.
TLDR
In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells, possibly contributes to their antiangiogenesis activity.
Spinal pathways mediating coeruleospinal antinociception in the rat
TLDR
The results suggest that interruption of descending inhibition from the LC/SC produced by the VLF transections is due to the blockage of axons descending in the ventrolateral quadrant of the spinal cord, but not in the dorsolateral Quadrant.
Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.
TLDR
A modified method by combining the CETSA and proteomics analysis based on 2D gel electrophoresis, namely 2DE-CETSA, to identify the thermal stability-shifted proteins by binding with a new compound is developed, applicable for identification of target compounds discovered by phenotypic screening.
Antiangiogenic activity of hypoxylonol C.
TLDR
Cell cycle arrest and suppression of adhesion molecule expression might be plausible mechanisms of actions for the antiangiogenic activity of hypoxylonol C (1) in HUVECs.
BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.
TLDR
It is shown that in response to vemurafenib, BRAF-mutated melanoma and colorectal cancer cells rapidly induced the ISR as a cytoprotective mechanism through activation of general control nonderepressible 2 (GCN2), an eIF2α kinase sensing amino acid levels, providing an insight into the development of drug resistance.
GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress
TLDR
It is found that a multikinase inhibitor, GZD824, which was identified using a cell-based assay with ATF4 immunostaining, inhibited the GCN2 pathway in cancer cells and sensitized certain cancer cells to amino acid starvation stress similarly to ATF4 knockdown.
Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy
TLDR
It is shown that oncogenic BRAF plays an essential role in the induction of ATF4 following the activation of general control non-derepressible 2 (GCN2) kinase during nutrient stress and BRAF-targeted, therapeutic stress and a chemical compound is identified that prevents BRAF inhibitor-induced activation of the GCN2-ATF4 pathway and produces synergistic cell killing with BRAF inhibitors.
Abstract 1893: The effect of kinase signaling for miR-205 regulation in gefitinib-resistant lung cancer cell lines
TLDR
This study performs characterization of gefitinib resistant cell lines and suggests that alterations of kinase signals are more effective for miR-205 regulation than protein expression of target molecule itself, such as ErbB3.
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