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Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs.
- Sarah T A Al-Rashood, Ihsan A Aboldahab, +6 authors H. El-Subbagh
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 December 2006
In order to produce potent new leads for anticancer drugs, a new series of quinazoline analogs was designed to resemble methotrexate (MTX, 1) structure features and fitted with functional groups… Expand