Ihor Lemischka

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Dissecting self-renewal in stem cells with RNA interference

Natalia N Ivanova, R. S. Dobrin, +6 authors Ihor Lemischka
Nature
2006

We present an integrated approach to identify genetic mechanisms that control self-renewal in mouse embryonic stem cells. We use short hairpin RNA (shRNA) loss-of-function techniques to downregulate… (More)

A stem cell molecular signature.

Natalia B Ivanova, John T Dimos, Christoph Schaniel, Jason A. Hackney, Kateri Moore, Ihor Lemischka
Science
2002

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells… (More)

Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network

Yen-Sin Ang, Su-yi Tsai, +12 authors Ihor Lemischka
Cell
2011

The embryonic stem (ES) cell transcriptional and chromatin-modifying networks are critical for self-renewal maintenance. However, it remains unclear whether these networks functionally interact and,… (More)

The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells

Qin Shen, Yue Wang, +7 authors Sally Temple
Nature Neuroscience
2006

In the developing cerebral cortex, neurons are born on a predictable schedule. Here we show in mice that the essential timing mechanism is programmed within individual progenitor cells, and its… (More)

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

Jianhua Ling, Ya'an Kang, +11 authors Paul J. Chiao
Cancer cell
2012

Constitutive Kras and NF-κB activation is identified as signature alterations in pancreatic ductal adenocarcinoma (PDAC). However, how NF-κB is activated in PDAC is not yet understood. Here, we… (More)

shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development.

Christopher A. Fasano, John T Dimos, Natalia B Ivanova, Natalia Lowry, Ihor Lemischka, Sally Temple
Cell stem cell
2007

Knockout studies have shown that the polycomb gene Bmi-1 is important for postnatal, but not embryonic, neural stem cell (NSC) self-renewal and have identified the cell-cycle inhibitors p16/p19 as… (More)

Stem cells and their niches.

A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal and differentiation in all stem cells. Stem cells, their progeny, and elements of their… (More)

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors.

K Mackarehtschian, Jeffrey D. Hardin, Kateri Moore, Sharon Boast, Stephen P Goff, Ihor Lemischka
Immunity
1995

The flk2 receptor tyrosine kinase has been implicated in hematopoietic development. Mice deficient in flk2 were generated. Mutants developed into healthy adults with normal mature hematopoietic… (More)

Patient-specific induced pluripotent stem cell derived models of LEOPARD syndrome

Xonia Carvajal-Vergara, Ana Sevilla, +18 authors Ihor Lemischka
Nature
2010

The generation of reprogrammed induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders holds the promise of increased understanding of the aetiologies of complex diseases… (More)

Systems-level dynamic analyses of fate change in murine embryonic stem cells

Rong Lu, Florian Markowetz, +10 authors Ihor Lemischka
Nature
2009

Molecular regulation of embryonic stem cell (ESC) fate involves a coordinated interaction between epigenetic, transcriptional and translational mechanisms. It is unclear how these different molecular… (More)

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