Igor Yu. Malyshev

Learn More
Preadaptation of cultured HT22 mouse hippocampal neurons to oxidative stress prevented cell damage induced by severe oxidative stress. This protection manifested in a decrease in metabolic disturbances in neurons. Adaptation of neurons to oxidative stress was accompanied by accumulation of HSP32 and HSP70. HSP synthesis inhibitor quercetin abolished the(More)
The phenomenon of adaptive stabilization of structures (PhASS) develops during adaptation of the organism to intermittent restraint stress. The PhASS manifests itself in a considerably increased resistance of the heart to a broad spectrum of harmful factors. In the present work, the content of hsp70 and their role in the development of PhASS during(More)
Adaptation of rats to repcated short-term stress exposure prevents, to a considerable extent, contractural and arrhythmogenic effects of high concentrations of extracellular Ca2+ on isolated heart. Increased efficiency of SR Ca2+-pump functioning and a significant increase in Ca2+ pump resistance to autolysis are proved to play the main role in this effect.
We studied the role of nitric oxide in the stress response and apoptosis. Intracellular nitric oxide potentiated the stress response. However, intracellular nitric oxide suppressed the stress response in macrophages of proinflammatory and antiinflammatory phenotypes. Intracellular nitric oxide promoted apoptosis in macrophages of the proinflammatory(More)
Accumulation of HSP70 stress proteins in the myocardium and blood content of nitrite/nitrate in August rats with modeled myocardial infarction surpassed these parameters in Wistar rats less resistant to cardiovascular disorders by 2-2.5 and 1.8 times, respectively. Our results suggest that various resistance of August and Wistar rats to myocardial(More)
In Wistar and August rats characterized by different resistance to acute emotional stress we compared the resistance to neurodegenerative brain damage (model of Alzheimer’s disease) produced by administration of a neurotoxic peptide fragment (25–35) β-amyloid into the brain. August rats were more resistant to acute stress and development of(More)
Adaptation of animals to short-term stress exposure (ASE) protected the heart against arrhythmias in acute ischemia and reperfusion and eliminated the decrease in threshold of fibrillation and arrhythmias in acute myocardial infarction and postinfarction cardiosclerosis. Cardioprotective effect of ASE was provided not only by the activation of GABAergic,(More)
By the open-field behavior, August rats were more resistant to acute hypoxia than Wistar rats. Hypoxic activation of the immune system was more pronounced in August rats. As differentiated from Wistar rats, the stress-limiting NO system in August rats was not suppressed during hypoxia. The effectiveness and resistance of this system to hypoxia were higher(More)
The resistance of August rats to ulceration of the gastric mucosa induced by acute emotional stress was higher than in Wistar rats. August rats exhibited not only more potent activation of the protective nitric oxide system and mobilization of the immune system, but also increased synthesis of cytoprotective heat shock proteins HSP70 in blood leukocytes(More)
Dosed adaptation to environmental factors is an efficient non-drug means for increasing the resistance of organs or the body as a whole. We demonstrated earlier that nitric oxide (NO) plays an important role in adaptive defense of the organism, in particular due to activation of heat shock protein (HSP) synthesis. A key question remained open—to what extent(More)