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RATIONALE Chronic mountain sickness or Monge's disease is characterized by an excessive polycythemia in high-altitude dwellers, with a prevalence of 5 to 18% above 3,200 m. To date, no pharmacologic treatment is available. OBJECTIVES We evaluated the efficacy of acetazolamide in the treatment of chronic mountain sickness and the importance of nocturnal(More)
BACKGROUND Morbidly obese patients have a high prevalence of known and unknown cardiopulmonary diseases. The aim of this study was to assess the value of cardiopulmonary tests routinely performed before bariatric surgery. METHODS The population studied included 67 women and 10 men, aged 39 +/- 10 years, with a body mass index of 43 +/- 4 kg/m2. All(More)
Sleep and respiration data from two French medical high altitude expeditions (Annapurna 4,800 m and Mt Sajama 6,542 m) are presented. Difficulties in maintaining sleep and a SWS decrease were found with periodic breathing (PB) during both non-REM and REM sleep. Extent of PB varied considerably among subjects and was not correlated to the number of arousals(More)
Post-malaria neurological syndrome (PMNS) defined by a post-infective encephalopathy occurring within 2 months after an episode of Plasmodium falciparum infection is still a debated entity. We describe 2 cases of PMNS in 2 patients of African origin, born and living in France. Both patients had severe P. falciparum infection, followed by PMNS. They(More)
In a first study, 28 pregnant women received a fast intravenous injection of atropine sulphate 12.5 µg/kg, as in a classical atropine test. Fetal tachycardia resulted. The maternal venous blood concentration of atropine, determined by bioassay on guinea pig ileum, decreased rapidly in the first 3–5 min and very slowly thereafter In a second study, 45 women(More)
Rat vas deferens preparations became desensitized to the alpha 1-adrenoceptor antagonist thymoxamine: after 6 h in vitro, the t 1/2 value (time to attain half the occupancy of receptors occupied at equilibrium) of the response to this drug was 1.50 fold greater in control strips (strips exposed to thymoxamine at 6 h) than in test strips (strips exposed to(More)
Guinea pig ileums in Tyrode solution develop a progressive desensitization to the effects of atropine (2-min exposure). This desensitization, followed carefully by a simplified method, is significant from the fourth hr. On the other hand, no desensitization develops to the effects of equilibrium exposure to atropine.
Guinea pig ileum developed in vitro a progressive desensitization to the antihistaminic agents mepyramine and benadryl. This desensitization had uncommon characteristics: (1) at the 6.5-9 h period of the experiments, it consisted only of a decreased rate of action of the drugs (1.66 fold and 2 fold increases in the 2 min Kb value of mepyramine and benadryl(More)
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