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BACKGROUND Reliable transcription factor binding site (TFBS) prediction methods are essential for computer annotation of large amount of genome sequence data. However, current methods to predict TFBSs are hampered by the high false-positive rates that occur when only sequence conservation at the core binding-sites is considered. RESULTS To improve this(More)
BACKGROUND The passage through the cell cycle is controlled by complexes of cyclins, the regulatory units, with cyclin-dependent kinases, the catalytic units. It is also known that cyclins form several families, which differ considerably in primary structure from one eukaryotic organism to another. Despite these lines of evidence, the relationship between(More)
The following hypothesis has been proposed: IF an SNP can significantly increase the expression of an oncogene by increasing the affinity of the TATA-binding protein (TBP) to its promoter, THEN this SNP can also reduce the apparent bioactivity of inhibitors of this oncogene during antitumor chemotherapy and vice versa. In the context of this hypothesis, the(More)
The tryptophan biosynthesis pathway is universal for the majority of known organisms, although it is absent in animals and some eubacteria. This pathway is conserved in plants, although various species differ in the number of paralogs of the enzymes involved in it. In this work, the possible role of the changes in the number of tryptophan biosynthesis(More)
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