Igor D Stolyarov

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Parameters of cell-mediated immunity were compared at the subacute stage of ischemic stroke in cases of the location of the lesion in the right or left hemisphere before and after transcranial electromagnetic stimulation (TMS). Patients with right-side strokes exhibited better restoration of the subpopulation composition of lymphocytes, their proliferation(More)
We analyzed the mechanisms of interaction between nervous and immune systems characterized by common principles of organization, common messenger molecules, and regulatory functions significant for the whole organism. Common components of neuroimmunity and nonimmune pathological processes underlie the possibility of their mutual potentiation [1].(More)
OBJECTIVE To investigate, in patients with Parkinson disease, the pharmacokinetics and pharmacodynamics of levodopa/carbidopa delivered via 3 different extended-release (ER) tablet formulations. METHODS This was a randomized, crossover study in patients with stable idiopathic Parkinson disease comparing a conventional ER tablet (C-ER) administered orally(More)
The mechanism of the development of cognitive impairments in multiple sclerosis (MS) was investigated by studying glucose metabolism at the level of the brain by positron emission tomography (PET). A total of 61 patients with different types of MS were studied. Correlation analysis identified a relationship between cognitive impairments and regional glucose(More)
The investigators conducted a single-dose pharmacokinetic (PK) study of levodopa/carbidopa delivered from novel gastric-retentive extended-release (ER) tablets versus a comparator ER tablet (M-ER) in patients with Parkinson's disease. Two levodopa/carbidopa (200 mg/50 mg) gastric-retentive ER formulations (4 hours and 6 hours) and M-ER were administered(More)
A total of 65 patients with clinically significant diagnoses of remitting multiple sclerosis in the stage of remission were studied. Neurological status was investigated with assessment on the FS and EDSS scales, with neuropsychological testing, and MRI scans (1.5 T). The severity of brain atrophy (in terms of the parenchyma volume) and the total volume of(More)
The article presents the literature data and results of our own researchon the use of positron emission tomography (PET) with different radiotracersin multiple sclerosis (MS). Informationon the operating principles of PET and PET studies with different radiotracers are considered. The results of PET studiesin different typesof MS, including determinationof(More)
The relationship between the parameters of the distribution of plantar pressure and the state of a patient with multiple sclerosis has been studied with repeated measurements, before and after (or during) treatment. The possibility of using this method for study of walking function impairment in a chronic demyelinating process is considered.
AIM To evaluate and compare the intensity of changes in a regional meta-analysis in relapsing-remitting and secondary-progressive multiple sclerosis (RRS and SPMS). MATERIAL AND METHODS The results of longitudinal studies of multiple sclerosis (MS) using positron emission tomography, magnetic resonance spectroscopy and diffusion tensor imaging are(More)