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Extracellular matrix can regulate multipotent mesenchymal stromal cells (MMSC) differentiation, with potential applications for tissue engineering. A relief of mineralized bone takes essential effect on MMSC fate. Nevertheless, delicate structure and a hierarchy of niches for stromal stem cells and its quantitative parameters are not practically known.(More)
The capacity of mouse bone marrow cells to adhere to calcium phosphate surfaces and form tissue plates depending on the surface relief and solubility was studied in ectopic bone formation test. Calcium phosphate coating of titanium disks, made by the anodic spark (microarch) oxidation in 10% orthophosphoric acid with hydroxyl apatite particles, differed by(More)
Samples of a hybrid composite of polyhydroxybutyrate (PHB), a biodegradable polyester, and hydroxyapatite (HA), with different PHB/HA ratios, have been prepared using mechanical-physical method. Electron microscopy, X-ray structure analysis and differential thermal analysis have been used to investigate the structure and physicochemical properties of the(More)
Correlation analysis demonstrated the role of inorganic parameters of the surfaces of calcium phosphate materials in the regulation of osteogenic differentiation of mesenchymal precursors. The progenitor stromal cells were isolated from syngeneic bone marrow immobilized in vitro on calcium phosphate surfaces with different structure, phasic, and elemental(More)
Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the(More)
Adhesion of pathogenic Staphylococcus aureus (strain 209) to BT1-0 titanium disks (12 mm in diameter) with different coatings and noncoated was studied in vitro by photocolorimetry. Transparency of bacterial suspension in normal saline was evaluated after 2-h culturing with the implants at 37 degrees C. The decrease of S. aureus content in the suspension(More)
It was demonstrated in experiments on rats that a neuroleptic and alpha-adrenergic blocking agent inhibited whereas a ganglion blocking agent and beta-adrenergic blocking agent delayed activation of granulocytopoiesis in immobilization stress, while M-cholinergic blocking agent had practically no effect on this process. Blockade of alpha- or beta-adrenergic(More)
The time course of compensation-adaptation reactions of bone marrow hemopoiesis-inducing microenvironment (HIM) was studied in F1 (CBA x C57BL/6) mice subjected to 10-hour immobilization. The number of macrophage and fibroblastoid colony-forming units, committed and stem precursor stroma cells responsible for HIM transport was shown to increase in the(More)