Development of resistance to therapy continues to be a serious clinical problem in breast cancer management. Cancer stem/progenitor cells have been shown to play roles in resistance to chemo‐ and radiotherapy. Here, we examined their role in the development of resistance to the oestrogen receptor antagonist tamoxifen. Tamoxifen‐resistant cells were enriched… (More)
The heterogeneous nature of breast cancer is a result of intrinsic tumor complexity and also of the tumor microenvironment, which is known to be hypoxic. We found that hypoxia expands different breast stem/progenitor cell populations (cells with increased aldehyde dehydrogenase activity (Aldefluor+), high mammosphere formation capacity and CD44+CD24-/low… (More)
This paper demonstrates how to achieve energy savings in the construction and operation of buildings by promoting the use of life cycle assessment techniques in the design for new buildings and for refurbishment. The paper aims to draw on the application of a specific methodology for low energy consumption, integrated planning, environmental performance… (More)
In this paper the kinematics, (position, velocities and accelerations) and the dynamics of a 6-RUS parallel manipulator by using the natural coordinates are analysed. One numerical example of kinematics and inverse dynamics is presented.