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It is widely recognized that the risk of fractures is closely related to the typical decline in bone mass during the ageing process in both women and men. Exercise has been reported as one of the best non-pharmacological ways to improve bone mass throughout life. However, not all exercise regimens have the same positive effects on bone mass, and the studies(More)
Across a wide range of species and body mass a close matching exists between maximal conductive oxygen delivery and mitochondrial respiratory rate. In this study we investigated in humans how closely in-vivo maximal oxygen consumption (VO(2) max) is matched to state 3 muscle mitochondrial respiration. High resolution respirometry was used to quantify(More)
OBJECTIVE The main purpose of this study was to determine the relationship between physical activity (PA) levels and adiposity. The secondary purpose was to assess the effect of physical fitness and living area on adiposity. RESEARCH METHODS AND PROCEDURES A cross-sectional study was carried out in a regional representative sample of 1068 children 7 to 12(More)
PURPOSE There is evidence to suggest a beneficial effect of physical activity on several mental disorders. METHODS The study aim was to assess the association between low physical activity during leisure time (or sedentary lifestyles) and the incidence of mental disorders in 10,381 participants, from a Spanish dynamic prospective cohort of university(More)
OBJECTIVE To study the effect of physical activity on whole body fat (BF), its regional deposition and the influence of body fatness on physical performance in prepubertal children. DESIGN Cross-sectional study. SUBJECTS A total of 114 boys (9.4+/-1.5 y, Tanner I-II), randomly sampled from the population of Gran Canaria (Spain), 63 of them physically(More)
AIM/HYPOTHESIS The aim of this study was to investigate mitochondrial function, fibre-type distribution and substrate oxidation during exercise in arm and leg muscles in male postobese (PO), obese (O) and age- and body mass index (BMI)-matched control (C) subjects. The hypothesis of the study was that fat oxidation during exercise might be differentially(More)
To examine whether obesity-associated leptin resistance could be due to down-regulation of leptin receptors (OB-Rs) and/or up-regulation of suppressor of cytokine signalling 3 (SOCS3) and protein tyrosine phosphatase 1B (PTP1B) in skeletal muscle, which blunt janus kinase 2-dependent leptin signalling and signal transducer and activator of transcription 3(More)
INTRODUCTION While current exercise guidelines recommend progressive, high-intensity resistance training (RT) to promote muscle hypertrophy and strength gains, controversy exists regarding the efficacy of lighter-load RT. We compared 2 work-matched RT interventions that differed in training intensity. METHODS Fifteen women underwent 10 weeks of unilateral(More)
The present study aimed at comparing fat and lean masses between children and adolescents with and without Down syndrome (DS) and evaluating the presence of sexual dimorphism. Total and regional fat and lean masses were assessed by dual energy X-ray absorptiometry (DXA) and the percentage of body fat (%BF) by air-displacement plethysmography (ADP) in 31(More)
Not much is known about the osteogenic effects of sport activities before puberty. We tested the hypothesis that football (soccer) participation is associated with enhanced bone mineral content (BMC) and areal density (BMD) in prepubertal boys. One hundred four healthy white boys (9.3 +/- 0.2 years, Tanner stages I-II) participated in this study: 53(More)