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This paper presents a novel computer-aided diagnosis (CAD) technique for the early diagnosis of the Alzheimer's disease (AD) based on nonnegative matrix factorization (NMF) and support vector machines (SVM) with bounds of confidence. The CAD tool is designed for the study and classification of functional brain images. For this purpose, two different brain(More)
Keywords: Support vector machines Computer-aided diagnosis Alzheimer's type dementia Feature extraction a b s t r a c t Alzheimer's disease (AD) is the most common cause of deme ntia in the elderly and affects approximately 30 million individuals worldwide. With the growth of the older population in developed nations , the prevalence of AD is expected to(More)
Parkinsonism is the second most common neurodegenerative disorder. It includes several pathologies with similar symptoms, what makes the diagnosis really difficult. I-ioflupane allows to obtain in vivo images of the brain that can be used to assist the PS diagnosis and provides a way to improve its accuracy. In this paper a new method for brain SPECT image(More)
638 Background: Head-to-head comparison of a steroidal aromatase inhibitor (AI) (E) vs. a non-steroidal AI (A) with crossover at the time of progression to evaluate the sequence of administration. Principal and secondary objectives were overall response rate (ORR), clinical benefit (CB) and time to progression (TTP). METHODS Postmenopausal pt with(More)
BACKGROUND A prospective randomized clinical trial was implemented to assess whether the concomitant or the sequential addition of tamoxifen to chemotherapy provides improved clinical benefit in the adjuvant treatment of breast cancer in postmenopausal patients. PATIENTS AND METHODS Four-hundred and eighty-five patients with node-positive operable disease(More)
An accurate and early diagnosis of the Alzheimer's Disease (AD) is of fundamental importance for the patients medical treatment. Single Photon Emission Computed Tomography (SPECT) images are commonly used by physicians to assist the diagnosis, rating them by visual evaluations. In this work we present a computer assisted diagnosis tool based on a Principal(More)
AIMS AND BACKGROUND To assess the efficacy of orgotein in the treatment of acute secondary effects of radiotherapy on head and neck tumors. MATERIAL AND METHODS Data were collected on 41 patients who received radiotherapy for tumors of the head and neck. Radiotherapy was the exclusive treatment in 19.5% of cases, with surgery in 24.4%, chemotherapy in(More)
The study of neurodegenerative diseases has been based for some time on visual and semi-quantitative analysis of medical imaging. This is the case of Parkinsonian Syndrome (PS) or Parkinsonism, which is the second most common neurodegenerative disorder, where 123 I-ioflupane (better known by its tradename, DaTSCAN) images have been of great help. Recently,(More)
Keywords: Alzheimer's disease (AD) Computer aided diagnosis Principal component analysis (PCA) Independent component analysis (ICA) Support vector machine (SVM) Supervised learning FDG-PET a b s t r a c t Finding sensitive and appropriate technologies for non-invasive observation and early detection of Alzheimer's disease (AD) is of fundamental importance(More)