Iftach Yacoby

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We have developed an immunization procedure for the production of effective anti-β-amyloid (anti-Aβ) antibodies, using filamentous phage displaying only 4 amino acids. The EFRH sequence, encompassing amino acids 3–6 of the 42 residues of Aβ peptide, was found previously to be the main regulatory site for amyloid modulation and the epitope of(More)
Amyloid-beta peptide (AbetaP) that accumulates in the Alzheimer's diseased brain is derived from proteolytic processing of the amyloid precursor protein (APP) by means of beta- and gamma-secretases. The beta-secretase APP cleaving enzyme (BACE), which generates the N terminus of AbetaP, has become a target of intense research aimed at blocking the enzyme(More)
Photosynthetic water splitting, coupled to hydrogenase-catalyzed hydrogen production, is considered a promising clean, renewable source of energy. It is widely accepted that the oxygen sensitivity of hydrogen production, combined with competition between hydrogenases and NADPH-dependent carbon dioxide fixation are the main limitations for its(More)
BACKGROUND Recombinant expression and purification of metallo-enzymes, including hydrogenases, at high-yields is challenging due to complex, and enzyme specific, post-translational maturation processes. Low fidelities of maturation result in preparations containing a significant fraction of inactive, apo-protein that are not suitable for biophysical or(More)
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