Iffat Rahim

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Intratumoral phenotypic diversity is well documented with regard to tumor associated carbohydrate antigens (TACA). The factors which control the expression of these cell-surface oligosaccharides on different cells of the same tumor are not understood. We investigated the expression of a panel of mucin associated oligosaccharides in cell lines growing at(More)
The levels of the cyclic nucleotides, cAMP and cGMP, in the medium of aging mass cultures of Panagrellus redivivus were determined, respectively, by a protein binding assay and a radio-immunoassay. The amount of cGMP increased as the mass cultures aged while the amount of cAMP remained stable. Since premature death and an inhibition of development have been(More)
1. Tissue levels of adenosine 3', 5'-cyclic monophosphate (c-AMP) were determined by a protein binding assay in mixed populations of the free living nematode Panagrellus redivivus. 2. The values were 2.6 pmoles/mg dry weight (range 1.3-3.4 pmoles). 3. The identity of the c-AMP assayed was confirmed by both anion exchange and TLC as well as enzymatic(More)
The extended Le(a)-Le(x) oligosaccharide, expressed as a cell surface antigen by human squamous lung carcinomas marks cancer cells of tumors having poor prognosis. In order to see if the extended Le(a)-Le(x) also has a precisely controlled pattern of expression during embryogenesis, a survey of representative vertebrate embryos and fetuses in various stages(More)
1. Tissue levels of guanosine 3',5'-cyclic monophosphate (c-GMP) were determined by radioimmunoassay in mixed-age populations of the free living nematode Panagrellus redivivus. 2. Cyclic-GMP was identified by chromatography (ion exchange and thin-layer) and by enzymatic degradation.
An immunohistochemical evaluation of Le(a)-Le(x) expression by adenocarcinomas of the biliary tree, pancreas, colon and stomach was undertaken as examples of epithelial tumors derived from embryonic endoderm. This complements previous studies showing that Lea-Lex was present on the cell surface of non-small cell lung carcinomas, some non-lung carcinomas,(More)
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