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MOTIVATION An 8-10mer can become a cytotoxic T lymphocyte epitope only if it is cleaved by the proteasome, transported by TAP and presented by MHC-I molecules. Thus most of the epitopes presented to cytotoxic T cells in the context of MHC-I molecules are products of intracellular proteasomal cleavage. These products are not random, as peptide production is(More)
Supervised learning is all about the ability to generalize knowledge. Specifically, the goal of the learning is to train a classifier using training data, in such a way that it will be capable of classifying new unseen data correctly. In order to acheive this goal, it is important to carefully design the learner, so it will not overfit the training data.(More)
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