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In silico drug discovery is a complex process requiring flexibility and ingenuity in method selection and a careful validation of work protocols. GPCR in silico drug discovery poses additional challenges due to the paucity of crystallographic data. This paper starts by reviewing selected GPCR in silico screening programs reported in the literature,(More)
Fuzzy sets theory is of great interest in medical image processing, for dealing with imprecise information and knowledge. It provides a consistent mathematical framework for knowledge representation, information modeling at different levels, fusion of heterogeneous information, reasoning and decision making. In this chapter, we provide an overview of the(More)
Defining the optimal clock-distribution network in VLSI is one of the most important aspect of high-speed SoC design. The existing design flows for clock tree network implementation are manual based and require long development cycle time. This long and iterative design flow is not optimized in terms of: Clock-skew, insertion delay, clock signal rise/fall(More)
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