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BACKGROUND There is a pressing need to identify novel pathophysiological pathways relevant to depression that can help to reveal targets for the development of new medications. Toll-like receptor 4 (TLR-4) has a regulatory role in the brain's response to stress. Psychological stress may compromise the intestinal barrier, and increased gastrointestinal(More)
The innate immune response is the first line of defence against invading microorganisms and it is also activated in different neurologic/neurodegenerative pathological scenarios. As a result, the family of the innate immune toll-like receptors (TLRs) and, in particular, the genetic/pharmacological manipulation of the TLR-4 signalling pathway emerges as a(More)
BACKGROUND Stressful challenges are associated with variations in immune parameters, including increased innate immunity/inflammation. Among possible mechanisms through which brain monitors peripheral immune responses, toll-like receptors (TLRs) recently emerged as the first line of defense against invading microorganisms. Their expression is modulated in(More)
Epidemiological observations report an increase in fat consumption associated with low intake of n-3 relative to n-6 polyunsaturated fatty acids (PUFAs) in women of childbearing age. However, the impact of these maternal feeding habits on cognitive function in the offspring is unknown. This study aims to investigate the impact of early exposure to a(More)
  • Juan Carlos Leza, José L Muñoz Madrigal, Dpto Farmacología, Fac, Medicina, Ucm +7 others
  • 2007
Brain Inflammatory/antinflammatory balance. Role of endogenous canabinoid system. Pathophysiology and pharmacology of stress-induced inflammatory and disfunctional processes in the gut. Markers of vulnerability of stress response. Molecular mechanisms of stress-induced changes on neuroinflammatory diseases. Hormonal regulation of stress inflammatory(More)
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