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  • Teppei Fujikawa, Jen-Chieh Chuang, Ichiro Sakata, Giorgio Ramadori, Roberto Coppari
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2010 (First Publication: 20 September 2010)
  • Leptin monotherapy reverses the deadly consequences and improves several of the metabolic imbalances caused by insulin-deficient type 1 diabetes (T1D) in rodents. However, the mechanism(s) underlyingExpand
  • Tong-Jin Zhao, Ichiro Sakata, +5 authors Jeffrey M. Zigman
  • Medicine, Biology, Chemistry
  • Proceedings of the National Academy of Sciences
  • 2010 (First Publication: 16 August 2010)
  • Ghrelin, an octanoylated peptide hormone produced in the stomach, rises dramatically in mouse plasma during chronic severe calorie deprivation, an event that is essential to maintain life. TheExpand