Ichiro Moriyama

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BACKGROUND CD5+ B cells are a type of regulatory immune cells, though the involvement of this B cell subset in intestinal inflammation and immune regulation is not fully understood. METHODS We examined the distribution of CD5+ B cells in various mouse organs. Expression levels of CD11b, IgM, and toll-like receptor (TLR)-4 and -9 in B cells were evaluated.(More)
BACKGROUND The relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. The aim of this study was to clarify the correlation of FC with disease extent and severity in UC patients. METHODS UC patients scheduled to undergo an ileocolonoscopy were enrolled and fecal samples for FC measurement(More)
PURPOSE Few reports have compared the clinical efficacy of a pH-dependent release formulation of mesalazine (pH-5-ASA) with a time-dependent release formulation (time-5-ASA). We examined whether pH-5-ASA is effective for active ulcerative colitis (UC) in patients resistant to time-5-ASA. METHODS We retrospectively and prospectively analyzed the efficacy(More)
The effect of potassium ion and membrane potential on the uptake of L-glutamate in microvilli (brush border) vesicles prepared from human term placenta was studied using a rapid filtration technique. The uptake of L-glutamate into microvilli vesicles is Na+ electrochemical gradient dependent and pre-equilibration of the vesicles with K+ stimulates(More)
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