Icaro A. Marques

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The prion protein (PrP) is implicated in the Transmissible Spongiform Encephalopathies (TSEs), which comprise a group of fatal neurodegenerative diseases affecting humans and other mammals. Conversion of cellular PrP (PrP(C)) into the scrapie form (PrP(Sc)) is the hallmark of TSEs. Once formed, PrP(Sc) aggregates and catalyzes PrP(C) misfolding into new(More)
Spasticity is a motor disorder that affects over 12 million people worldwide. Its pathophysiology is rather complex and might be caused by cortical problems or spinal cord injury, for example, and involves different circuitries and networks. The measurement of spasticity is very important for providing better support for the patients, both in diagnosis and(More)
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