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Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.

• Kristopher L. Nazor, Gulsah Altun, +21 authors Louise Chang Laurent
• Cell stem cell
• 2012

Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and development, drug discovery, and regenerative medicine. However, it is important to identify factors that… (More)

Sphingolipids function as downstream effectors of a fungal PAQR.

• Nancy Yaneth Villa, Brian R. Kupchak, +6 authors Thomas J. Lyons
• Molecular pharmacology
• 2009

The Izh2p protein from Saccharomyces cerevisiae belongs to the newly characterized progestin and adipoQ receptor (PAQR) superfamily of receptors whose mechanism of signal transduction is still… (More)

Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.

• Jessica Smith, Brian R. Kupchak, +4 authors Thomas J. Lyons
• Steroids
• 2008

The nuclear progesterone receptor (nPR) mediates many of the physiological effects of progesterone by regulating the expression of genes, however, progesterone also exerts non-transcriptional… (More)

Adiponectin identified as an agonist for PAQR3/RKTG using a yeast-based assay system.

• Ibon Garitaonandia, Jessica Smith, Brian R. Kupchak, Thomas J. Lyons
• Journal of receptor and signal transduction…
• 2009

The PAQR family of proteins comprises an intriguing group of newly discovered receptors. Although the agonist is known for 5 of the 11 human PAQRs, most are considered "orphan" receptors. We… (More)

Induced pluripotent stem cells from highly endangered species

• Inbar Friedrich Ben-Nun, Susanne C Montague, +8 authors Jeanne F Loring
• Nature Methods
• 2011

For some highly endangered species there are too few reproductively capable animals to maintain adequate genetic diversity, and extraordinary measures are necessary to prevent extinction. We report… (More)

Teratoma Generation in the Testis Capsule

• Suzanne E. Peterson, Ha Thanh Nguyen Tran, +5 authors Jeanne F Loring
• Journal of visualized experiments : JoVE
• 2011

Pluripotent stem cells (PSCs) have the unique characteristic that they can differentiate into cells from all three germ layers. This makes them a potentially valuable tool for the treatment of many… (More)

Proof of concept studies exploring the safety and functional activity of human parthenogenetic-derived neural stem cells for the treatment of Parkinson's disease.

• Rodolfo Gonzalez, Ibon Garitaonandia, +10 authors Ruslan A. Semechkin
• Cell transplantation
• 2015

Recent studies indicate that human pluripotent stem cell (PSC)-based therapies hold great promise in Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural tissue can achieve… (More)

Probing the mechanism of FET3 repression by Izh2p overexpression.

• Brian R. Kupchak, Ibon Garitaonandia, +5 authors Thomas J. Lyons
• Biochimica et biophysica acta
• 2007

We previously reported a role for the IZH2 gene product in metal ion metabolism. Subsequently, Izh2p was also identified as a member of the PAQR family of receptors and, more specifically, as the… (More)

Antagonism of human adiponectin receptors and their membrane progesterone receptor paralogs by TNFalpha and a ceramidase inhibitor.

• Brian R. Kupchak, Ibon Garitaonandia, Nancy Yaneth Villa, Jessica Smith, Thomas J. Lyons
• Biochemistry
• 2009

The progestin and AdipoQ receptor (PAQR) family of proteins comprises three distinct structural classes, each with seemingly different agonist specificities. For example, Class I receptors, like the… (More)

Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease.

• Rodolfo Gonzalez, Ibon Garitaonandia, +18 authors Russell A Kern
• Cell transplantation
• 2016

Cell therapy has attracted considerable interest as a promising therapeutic alternative for patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural tissue can… (More)

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