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Neurotransmitter release at synapses between nerve cells is mediated by calcium-triggered exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at the presynaptic release site where they mature to a fusion-competent state. Here we identify Munc13-1, a brain-specific presynaptic phorbol ester receptor, as an essential protein for synaptic(More)
Munc13-1, a mammalian homologue of Caenorhabditis elegans unc-13p, is a presynaptic phorbol ester receptor that enhances neurotransmitter release. In the present study we analysed the regional, cellular and subcellular expression patterns in rat of two novel Munc13 proteins, Munc13-2 and Munc13-3. We demonstrate by hybridization in situ that Munc13-1 mRNA(More)
Munc13 proteins form a family of three, primarily brain-specific phorbol ester receptors (Munc13-1/2/3) in mammals. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. In contrast to Munc13-1, which is present in most neurons throughout the rat and mouse CNS, Munc13-3 is almost exclusively(More)
The Mobile Computing has emerged as a new field, distinct from conventional distributed computing by its focus on mobility and its consequence. The physical and logical mobility needs of applications with new requirements: built-in mobility, adaptability and flexibility. Providing a system architecture that simplifies the task of implementing the mobile(More)
The idea of ubiquitous learning is to create a network of devices, people and situation that allows learning experiences to play out. This idea is attractive but it is not easily implemented. The GlobalEdu is a ubiquitous learning architecture integrated in ISAM, a software architecture that manages a large-scale pervasive environment. This paper presents a(More)
The idea of pervasive learning is to create a network of devices, people and situation that allow learning experiences to play out. This idea is attractive, but is not easily implemented. This paper presents a pervasive learning architecture called GlobalEdu which is composed by educational services (ES) and pervasive personal pedagogical agent (P3A)(More)