Iara Augustin

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Neurotransmitter release at synapses between nerve cells is mediated by calcium-triggered exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at the presynaptic release site where they mature to a fusion-competent state. Here we identify Munc13-1, a brain-specific presynaptic phorbol ester receptor, as an essential protein for synaptic(More)
Munc13-1, a mammalian homologue of Caenorhabditis elegans unc-13p, is a presynaptic phorbol ester receptor that enhances neurotransmitter release. In the present study we analysed the regional, cellular and subcellular expression patterns in rat of two novel Munc13 proteins, Munc13-2 and Munc13-3. We demonstrate by hybridization in situ that Munc13-1 mRNA(More)
Munc13 proteins form a family of three, primarily brain-specific phorbol ester receptors (Munc13-1/2/3) in mammals. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. In contrast to Munc13-1, which is present in most neurons throughout the rat and mouse CNS, Munc13-3 is almost exclusively(More)
The Mobile Computing has emerged as a new field, distinct from conventional distributed computing by its focus on mobility and its consequence. The physical and logical mobility needs of applications with new requirements: built-in mobility, adaptability and flexibility. Providing a system architecture that simplifies the task of implementing the mobile(More)
The idea of ubiquitous learning is to create a network of devices, people and situation that allows learning experiences to play out. This idea is attractive but it is not easily implemented. The GlobalEdu is a ubiquitous learning architecture integrated in ISAM, a software architecture that manages a large-scale pervasive environment. This paper presents a(More)
In this paper we present an overview of EXEHDA, an adaptive, services-oriented middleware, conceived to support the execution of pervasive applications and the management of a pervasive environment. EXEHDA is being developed in the context of the ISAM project, which aims to provide an integrated solution, from development to execution, for general-purpose(More)
The Pervasive Computing is embedded in the development of programmable and interactive environments, and it seeks to help the user in their daily activities. Considering that health system of the future requires the use of Pervasive Computing to optimize and automate clinical activities, this paper presents the architecture ClinicSpace, demonstrating(More)
Ribbon synapses, for example of the retina, are specialized synapses that differ from conventional, phasically active synapses in several aspects. Ribbon synapses can tonically and yet very rapidly release neurotransmitter via synaptic vesicle exocytosis. This requires an optimization of the synaptic machinery and is at least partly due to the presence of(More)