Ian Yen-Hung Chen

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UNLABELLED Myocardial infarction (MI) leads to left ventricular (LV) remodeling, which leads to the activation of growth factors such as vascular endothelial growth factor (VEGF). However, the kinetics of a growth factor's receptor expression, such as VEGF, in the living subject has not yet been described. We have developed a PET tracer (64Cu-DOTA-VEGF121(More)
— Mobile robots are increasingly entering the real and complex world of humans in ways that necessitate a high degree of interaction and cooperation between human and robot. Complex simulation models, expensive hardware setup, and a highly controlled environment are often required during various stages of robot development. There is a need for robot(More)
PURPOSE To determine if magnetotactic bacteria can target tumors in mice and provide positive contrast for visualization using magnetic resonance imaging. EXPERIMENTAL DESIGN The ability of the magnetotactic bacterium, Magnetospirillum magneticum AMB-1 (referred to from here as AMB-1), to confer positive magnetic resonance imaging contrast was determined(More)
Stem cell therapy offers exciting promise for treatment of ischemic heart disease. Recent advances in molecular imaging techniques now allow investigators to monitor cell fate noninvasively and repetitively. Here we examine the effects of a triple-fusion reporter gene on embryonic stem (ES) cell transcriptional profiles. Murine ES cells were stably(More)
The objective of this research is to apply markerless Augmented Reality (AR) techniques to aid in the visualisation of robotic helicopter related tasks. Conventional robotic AR applications work well with markers in prepared environments but are infeasible in outdoor settings. In this paper, we present preliminary results from a real time mark-erless AR(More)
MRI is emerging as a diagnostic modality to track iron-oxide-labeled stem cells. This study investigates whether an off-resonance (OR) pulse sequence designed to generate positive contrast at 1.5T can assess the location, quantity, and viability of delivered stem cells in vivo. Using mouse embryonic stem cell transfected with luciferase reporter gene(More)
— Unified testing of multiple heterogeneous robotic software components is a challenging problem and many robotic systems rely on vendor-specific tools for testing and evaluation of individual subsystems. The consequence is often the unexpected interactions between components that arise during system integration. OpenRTM-aist is a distributed software(More)
Experimentation of expensive robot systems typically requires complex simulation models and expensive hardware setups for constructing close-to-real world environments in order to obtain reliable results and draw insights to the actual operation. However, the test-development cycle is often time-consuming and resource demanding. A cost-effective solution is(More)
Heart disease remains a leading cause of mortality and a major worldwide healthcare burden. Recent advances in stem cell biology have made it feasible to derive large quantities of cardiomyocytes for disease modeling, drug development, and regenerative medicine. The discoveries of reprogramming and transdifferentiation as novel biological processes have(More)