Ian R. Macfarlane

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1. Buprenorphine is a highly lipophilic derivative of oripavine. In rodent antinociceptive assays (writhing, tail pressure), buprenorphine had an action which was rapid in onset and of long duration; it was 25-40 times more potent than morphine after parenteral injection and 7-10 times more potent after oral administration. 2. The log dose-response(More)
Since an abstinence syndrome may accompany the injection of opioids in addicts pretreated with propranolol the morphine antagonistic properties of this compound were investigated. Racemic propranolol did not significantly affect the antinociceptive ED50 of morphine in rodents and neither precipitated abstinence in morphine-dependent monkeys nor exacerbated(More)
Since it has been reported that the narcotic antagonist analgesic, cyclazocine, has thymoleptic activity in man, certain neuropharmacological properties of this compound have been retrospectively analysed in rodents using diprenorphine, naloxone and RX 336-M (7,8-dihydro-5′, 6′-dimethylcyclohex-5′-eno 1′, 2′, 8′, 14 codeinone) as reference narcotic(More)
Prior to attempting to develop a new laxative, pharmacodynamic studies were conducted on the individual active constituents of senna. Sennoside A, sennoside B and rhein were injected intravenously and were introduced into the isolated stomach, small bowel and large bowel of the anaesthetised pig. Blood, urine and bile, collected over 6 hours, were assayed(More)
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