Ian R. Holmes

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We present a new probabilistic model of sequence evolution, allowing indels of arbitrary length, and give sequence alignment algorithms for our model. Previously implemented evolutionary models have allowed (at most) single-residue indels or have introduced artifacts such as the existence of indivisible "fragments." We compare our algorithm to these(More)
Transposable elements (TEs), or transposons, form a major fraction of the eukaryotic genome (Kidwell and Lisch 2001). Dismissed for some time as junk DNA, these repetitive sequences are now recognized for their diverse evolutionary roles. In this issue of Genome Research, Bao and Eddy (2002) describe a software tool (RECON) for de novo annotation of(More)
fungicides controlled downy mildew by reducing both the numbers of leaves with sporangia and the area of sporulation (Table 1). The protectant fungicides mancozeb and copper oxychloride both significantly reduced the area of sporulation when applied after inoculation. At most times of application, both the systemic formulations of metalaxyl and phosteyl-AI(More)
In this paper the authors present the RealityGrid PDA and Smartphone Clients: two novel and highly effective handheld user interface applications, which have been created purposefully to deliver (as a convenience tool) flexible and readily available ‘around the clock’ user access to scientific applications running on the Grid. A discussion is provided(More)
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