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This article reviews the event-related potential (ERP) literature in relation to the P2 waveform of the human auditory evoked potential. Within the auditory evoked potential, a positive deflection at approximately 150-250 ms is a ubiquitous feature. Unlike other cognitive components such as N1 or the P300, remarkably little has been done to investigate the(More)
The K-complex was first described by Loomis et al 67 years ago in a paper that was one of a series of seminal studies of sleep conducted in Loomis' private laboratory. The study of the K-complex was almost immediately taken up by many notable figures in early electroencephalography research, such as Robert Schwab, Mary Brazier, and W. Gray Walter. More than(More)
Numerous cross-sectional MRI studies have characterized age-related differences in regional brain volumes that differ with structure and tissue type. The extent to which cross-sectional assumptions about change are accurate depictions of actual longitudinal measurement remains controversial. Even longitudinal studies can be limited by the age range of(More)
STUDY OBJECTIVES To evaluate the impact of estrogen and estrogen plus progesterone hormone-replacement therapy (HRT) on mild-to-moderate sleep-disordered breathing (SDB) in postmenopausal women. DESIGN AND SETTING Within-subjects, progesterone placebo-controlled prospective HRT trial in a clinical laboratory. PARTICIPANTS Six postmenopausal women,(More)
The present study assessed the effects of occlusion duration and attention on components of the respiratory-related evoked potential (RREP). Twenty-nine channel evoked potential recordings were obtained from 12 young adults exposed to a pseudorandom sequence of 100-, 200-, 400-, and 800-ms inspiratory occlusions, under attend and ignore conditions. Results(More)
This study investigated the relationship between resistive load magnitude, load magnitude estimation, and the respiratory-related evoked potential. In Part 1, 10 healthy subjects estimated the magnitude of five inspiratory resistive loads. Two subjects were shown to have a markedly reduced slope of the magnitude estimation-resistive load relationship and(More)
BACKGROUND Obstructive sleep apnea (OSA) is a major problem in need of new treatment approaches. The present pilot study tests the hypothesis that the application of expiratory resistance via a nasal valve device would improve breathing during sleep in subjects with OSA and in primary snorers. METHODS Thirty men and women were recruited from the community(More)
STUDY OBJECTIVES To determine whether the cortical response to mid-inspiratory occlusions can be used as a model of the cortical response to obstructive events during sleep; and to determine whether the vertex sharp wave (VSW) and K-complex are exclusive contributors to the N350 and N550 components respectively of the stage 2 sleep event-related potential.(More)
Aging is associated with many changes in sleep, with one of the most prominent being a reduction in slow wave sleep. Traditional measures of this phenomenon rely on spontaneous activity and typically confound the incidence and amplitude of delta waves. The measurement of evoked K-complexes during sleep, enable separate assessment of incidence and amplitude(More)
STUDY OBJECTIVES To evaluate the accuracy in measuring nighttime sleep of a fitness tracker (Jawbone UP) compared to polysomnography (PSG). DESIGN Jawbone UP and PSG data were simultaneously collected from adolescents during an overnight laboratory recording. Agreements between Jawbone UP and PSG sleep outcomes were analyzed using paired t tests and(More)