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These guidelines explain how to make Web content [p. 26] accessible to people with disabilities. The guidelines are intended for all Web content developers [p. 26] (page authors and site designers) and for developers of authoring tools [p. 25]. The primary goal of these guidelines is to promote accessibility. However, following them will also make Web(More)
Authors: See acknowledgments (§8). Please refer to the errata for this document, which may include some normative corrections. document use and software licensing rules apply. Your interactions with this site are in accordance with our public and Member privacy statements. Abstract The World Wide Web uses relatively simple technologies with sufficient(More)
BACKGROUND Ovarian cancer has a high case-fatality ratio, with most women not diagnosed until the disease is in its advanced stages. The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is a randomised controlled trial designed to assess the effect of screening on mortality. This report summarises the outcome of the prevalence(More)
Its mission is to identify and review international science and knowledge relevant to cardiopulmo-nary resuscitation (CPR) and emergency cardiovascular care (ECC) and when there is consensus to offer treatment recommendations. Emergency cardiovascular care includes all responses necessary to treat sudden life-threatening events affecting the cardiovascular(More)
Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by(More)
OBJECTIVE To document the prevalence of hypothermia in a mass participation endurance open water swimming event and to determine demographic and individual factors that may predict failure to finish the race and hypothermia. METHODS A prospective observational study in competitors in a 19.2-km open water swimming race in Perth, Western Australia. Pre-race(More)
BACKGROUND There is little evidence from clinical trials that the use of adrenaline (epinephrine) in treating cardiac arrest improves survival, despite adrenaline being considered standard of care for many decades. The aim of our study was to determine the effect of adrenaline on patient survival to hospital discharge in out of hospital cardiac arrest. (More)
MALDI MS profiling, using easily available body fluids such as blood serum, has attracted considerable interest for its potential in clinical applications. Despite the numerous reports on MALDI MS profiling of human serum, there is only scarce information on the identity of the species making up these profiles, particularly in the mass range of larger(More)
OBJECTIVE Current resuscitation guidelines recommend that defibrillation be undertaken as soon as possible in patients suffering a cardiac arrest where the cardiac rhythm is either ventricular fibrillation (VF) or ventricular tachycardia (VT). Evidence from animal and clinical studies suggests that outcomes may be improved if a period of cardiopulmonary(More)
OBJECTIVE To describe the factors that contributed to successful recruitment of more than 200,000 women to the UK Collaborative Trial of Ovarian Cancer Screening, one of the largest ever randomised controlled trials. DESIGN Descriptive study. SETTING 13 NHS trusts in England, Wales, and Northern Ireland. PARTICIPANTS Postmenopausal women aged 50-74;(More)