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The World Wide Web uses relatively simple technologies with sufficient scalability, efficiency and utility that they have resulted in a remarkable information space of interrelated resources, growing across languages, cultures, and media. In an effort to preserve these properties of the information space as the technologies evolve, this architecture(More)
These guidelines explain how to make Web content [p. 26] accessible to people with disabilities. The guidelines are intended for all Web content developers [p. 26] (page authors and site designers) and for developers of authoring tools [p. 25] . The primary goal of these guidelines is to promote accessibility. However, following them will also make Web(More)
BACKGROUND Ovarian cancer has a high case-fatality ratio, with most women not diagnosed until the disease is in its advanced stages. The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is a randomised controlled trial designed to assess the effect of screening on mortality. This report summarises the outcome of the prevalence(More)
Outcome following cardiac arrest and cardiopulmonary resuscitation is dependent on critical interventions, particularly early defibrillation, effective chest compressions, and advanced life support. Utstein-style definitions and reporting templates have been used extensively in published studies of cardiac arrest, which has led to greater understanding of(More)
Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by(More)
Mary Fran Hazinski, Co-Chair*; Jerry P. Nolan, Co-Chair*; John E. Billi; Bernd W. Böttiger; Leo Bossaert; Allan R. de Caen; Charles D. Deakin; Saul Drajer; Brian Eigel; Robert W. Hickey; Ian Jacobs; Monica E. Kleinman; Walter Kloeck; Rudolph W. Koster; Swee Han Lim; Mary E. Mancini; William H. Montgomery; Peter T. Morley; Laurie J. Morrison; Vinay M.(More)
Note From the Writing Group: Throughout this article, the reader will notice combinations of superscripted letters and numbers (eg, “Initial Recognition ”). These callouts are hyperlinked to evidence-based worksheets, which were used in the development of this article. An appendix of worksheets, applicable to this article, is located at the end of the text.(More)
BACKGROUND High-throughput proteomic methods for disease biomarker discovery in human serum are promising, but concerns exist regarding reproducibility of results and variability introduced by sample handling. This study investigated the influence of different preanalytic handling methods on surface-enhanced laser desorption/ionization time-of-flight mass(More)
BACKGROUND There is little evidence from clinical trials that the use of adrenaline (epinephrine) in treating cardiac arrest improves survival, despite adrenaline being considered standard of care for many decades. The aim of our study was to determine the effect of adrenaline on patient survival to hospital discharge in out of hospital cardiac arrest. (More)
OBJECTIVE To describe the factors that contributed to successful recruitment of more than 200,000 women to the UK Collaborative Trial of Ovarian Cancer Screening, one of the largest ever randomised controlled trials. DESIGN Descriptive study. SETTING 13 NHS trusts in England, Wales, and Northern Ireland. PARTICIPANTS Postmenopausal women aged 50-74;(More)