Ian Gopal Gould

Learn More
OBJECTIVE Oxygen tension in the brain is controlled by the microcirculatory supply of RBC, but the effect of non-Newtonian blood flow rheology on tissue oxygenation is not well characterized. This study assesses different biphasic blood flow models for predicting tissue oxygen tension as a function of microcirculatory hemodynamics. METHODS Two existing(More)
The three-dimensional spatial arrangement of the cortical microcirculatory system is critical for understanding oxygen exchange between blood vessels and brain cells. A three-dimensional computer model of a 3 × 3 × 3 mm3 subsection of the human secondary cortex was constructed to quantify oxygen advection in the microcirculation, tissue oxygen perfusion,(More)
Although the conjugated linoleic acids (CLA) have several isomer-specific biological effects including anti-carcinogenic and anti-adipogenic effects, their mechanisms of action remain unclear. To determine their potential effects on membrane structure and function, we studied the incorporation profiles of four CLA isomers (trans-10 cis-12 (A), trans-9(More)
Experimental evidence has cast doubt on the classical model of river-like cerebrospinal fluid (CSF) flow from the choroid plexus to the arachnoid granulations. We propose a novel model of water transport through the parenchyma from the microcirculation as driven by Starling forces. This model investigates the effect of osmotic pressure on water transport(More)
The cortical angioarchitecture is a key factor in controlling cerebral blood flow and oxygen metabolism. Difficulties in imaging the complex microanatomy of the cortex have so far restricted insight about blood flow distribution in the microcirculation. A new methodology combining advanced microscopy data with large scale hemodynamic simulations enabled us(More)
Address correspondence to A. A. Linninger, Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan St, 218 SEO, M/C 063, Chicago, IL 60607-7000, USA. Electronic mail: linninge@uic.edu The online version of the original article can be found under doi: 10.1007/s10439-013-0828-0. Annals of Biomedical Engineering, Vol. 42, No. 8, August(More)
www.cmj.hr www.cmj.hr Experimental evidence has cast doubt on the classical model of river-like cerebrospinal fluid (CSF) flow from the choroid plexus to the arachnoid granulations. We propose a novel model of water transport through the parenchyma from the microcirculation as driven by Starling forces. This model investigates the effect of osmotic pressure(More)
  • 1